Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Post-Transplant Cyclophosphamide Versus Anti-Thymocyte Globulin As Graft- Versus-Host Disease Prophylaxis in Haploidentical Transplant Publisher Pubmed



Ruggeri A1 ; Sun Y2 ; Labopin M1, 3 ; Bacigalupo A4 ; Lorentino F5 ; Arcese W6 ; Santarone S7 ; Gulbas Z8 ; Blaise D9 ; Messina G10 ; Ghavamzadeh A11 ; Malard F1 ; Bruno B12 ; Diezmartin JL13 Show All Authors
Authors
  1. Ruggeri A1
  2. Sun Y2
  3. Labopin M1, 3
  4. Bacigalupo A4
  5. Lorentino F5
  6. Arcese W6
  7. Santarone S7
  8. Gulbas Z8
  9. Blaise D9
  10. Messina G10
  11. Ghavamzadeh A11
  12. Malard F1
  13. Bruno B12
  14. Diezmartin JL13
  15. Koc Y14
  16. Ciceri F5
  17. Mohty M1, 3, 15
  18. Nagler A15, 16, 17

Source: Haematologica Published:2017


Abstract

Severe graft-versus-host disease is a major barrier for non-T-celldepleted haploidentical stem cell transplantation. There is no consensus on the optimal graft-versus-host disease prophylaxis. This study compared the two most commonly used graft-versus-host disease prophylaxis regimens (post-transplant cyclophosphamide-based vs. the anti-thymocyte globulin-based) in adults with acute myeloid leukemia reported to the European Society for Blood and Bone Marrow Transplantation. A total of 308 patients were analyzed; 193 received posttransplant cyclophosphamide-based regimen and 115 anti-thymocyte globulin-based regimen as anti-graft-versus-host disease prophylaxis. The post-transplant cyclophosphamide-based regimen was more likely to be associated to bone marrow as graft source (60% vs. 40%; P=0.01). Patients in the post-transplant cyclophosphamide-based regimen group had significantly less grade 3-4 acute graft-versus-host disease than those in the anti-thymocyte globulin-based group (5% vs. 12%, respectively; P=0.01), comparable to chronic graft-versus-host disease. Multivariate analysis showed that non-relapse mortality was lower in the post-transplant cyclophosphamide-based regimen group [22% vs. 30%, Hazard ratio (HR) 1.77(95%CI: 1.09-2.86); P=0.02] with no difference in relapse incidence. Patients receiving post-transplant cyclophosphamide-based regimen had better graft-versus-host disease-free, relapse-free survival [HR 1.45 (95%CI: 1.04-2.02); P=0.03] and leukemia-free survival [HR 1.48 (95%CI: 1.03-2.12); P=0.03] than those in the anti-thymocyte globulinbased group. In the multivariate analysis, there was also a trend for a higher overall survival [HR 1.43 (95%CI: 0.98-2.09); P=0.06] for post-trans- plant cyclophosphamide-based regimen versus the anti-thymocyte globulin-based group. Notably, center experience was also associated with nonrelapse mortality and graft-versus-host disease-free, relapse-free survival. Haplo-SCT using a post-transplant cyclophosphamide-based regimen can achieve better leukemia-free survival and graft-versus- host disease-free, relapse-free survival, lower incidence of graft-versus-host disease and nonrelapse mortality as compared to anti-thymocyte globulin-based graft-versus-host disease prophylaxis in patients with acute myeloid leukemia. © 2017 Ferrata Storti Foundation.
Other Related Docs
15. Long--Term Free Survival of Two Class Iii Β-Thalassemic Patients After Non-Myeloablative Stem Cell Transplantation, International Journal of Hematology-Oncology and Stem Cell Research (2020)