Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Meta-Analysis of Human Papillomavirus Prevalence and Types Among Iranian Women With Normal Cervical Cytology, Premalignant Lesions, and Cervical Cancer Publisher Pubmed



Salavatiha Z1 ; Farahmand M1 ; Shoja Z2 ; Jalilvand S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, Pasteur Institute of Iran, Tehran, Iran

Source: Journal of Medical Virology Published:2021


Abstract

In this study, all data from Iran on human papillomavirus (HPV) prevalence and types among women with normal cervical cytology, premalignant lesions, and cervical cancer were obtained and pooled. The overall HPV prevalence was found to be 9% in women with a normal cervix, 55% in atypical squamous cells of undetermined significance or atypia cases, 58% and 69% in women with low and high grade squamous intraepithelial lesions, respectively, and 81% among women with invasive cervical cancer. In all of the studied groups, HPV 16 was the most common HPV type, followed by HPV 18. In conclusion, this meta-analysis revealed that it will be beneficial if current HPV vaccines are integrated into the national vaccination programs of Iran. © 2021 Wiley Periodicals LLC
Related Docs
View other Related Docs
1. A Meta-Analysis on Human Papillomavirus Type Distribution Among Women With Cervical Neoplasia in the Who Eastern Mediterranean Region, Intervirology (2019)
2. Systematic Review and Meta-Analysis of Human Papillomavirus Prevalence and Types Among Women With Normal Cervical Cytology in the Eastern Mediterranean Region, Future Virology (2019)
3. Meta-Analysis of Type-Specific Human Papillomavirus Prevalence in Iranian Women With Normal Cytology, Precancerous Cervical Lesions and Invasive Cervical Cancer: Implications for Screening and Vaccination, Journal of Medical Virology (2015)
4. Type-Specific Human Papillomavirus Prevalence in Cervical Intraepithelial Neoplasia and Cancer in Iran, Journal of Medical Virology (2018)
5. Type-Specific Human Papillomavirus Prevalence in Iranian Women With Normal Cervical Cytology: The Impact of Current Hpv Vaccines, Intervirology (2018)
6. Distribution of Human Papillomavirus Genotypes in Suspected Women Cytological Specimens From Tehran, Iran, Iranian Journal of Microbiology (2022)
7. Lineage Analysis of Human Papillomavirus Type 39 in Cervical Samples of Iranian Women, Virology Journal (2021)
8. Co‐Administration of 2’3’-Cgamp Sting Activator and Cpg-C Adjuvants With a Mutated Form of Hpv 16 E7 Protein Leads to Tumor Growth Inhibition in the Mouse Model, Infectious Agents and Cancer (2021)
Experts (# of related papers)
View all Related Experts
Somayeh Jalilvand (19)
Shohreh Shahmahmoodi Sadeghi (3)
Other Related Docs
9. Distribution of Human Papillomavirus Genotypes in Iranian Women According to the Severity of the Cervical Lesion, Iranian Red Crescent Medical Journal (2016)
10. The Prevalence of Human Herpesvirus 8 in Normal, Premalignant, and Malignant Cervical Samples of Iranian Women, Virology Journal (2021)
11. Lineage Analysis of Human Papillomavirus Type 18 Based on E6 Region in Cervical Samples of Iranian Women, Journal of Medical Virology (2020)
12. The Prevalence of Epstein-Barr Virus in Normal, Premalignant, and Malignant Uterine Cervical Samples in Iran, Intervirology (2024)
13. Prevalence of Human Papilloma Virus (Hpv) Genotypes Between Outpatients Males and Females Referred to Seven Laboratories in Tehran, Iran, Infectious Agents and Cancer (2022)
14. Prevalence and Genotype Distribution of Human Papillomavirus Infection Among 12 076 Iranian Women, International Journal of Infectious Diseases (2021)
15. Uncommon High Distribution of Hpv-16, Hpv-54, and Hpv-56 in Female Referred to a Laboratory in Karaj, Iran: Indications of a Paradigm Shift in Hpv Genotypes?, Virology Journal (2024)
16. Lineage and Sublineage Analysis of Human Papillomavirus Type 58 in Iranian Women, Virology Journal (2024)
17. Lineage Analysis of Human Papillomavirus Types 31 and 45 in Cervical Samples of Iranian Women, Journal of Medical Virology (2021)
18. The Prevalence and Genotype Distribution of Cervical Human Papillomavirus Dna in Women With Normal Cytology in North of Iran, Jundishapur Journal of Microbiology (2017)
19. Variant Analysis of Human Papillomavirus Type 52 in Iranian Women During 2018−2020: A Case-Control Study, Health Science Reports (2024)
20. Human Papillomavirus Type 16 Lineage Analysis Based on E6 Region in Cervical Samples of Iranian Women, Infection# Genetics and Evolution (2017)
21. Relative Frequency of Human Papillomavirus Genotypes and Related Sociodemographic Characteristics in Women Referred to a General Hospital in Tehran, 2014-2015: A Cross-Sectional Study, International Journal of Reproductive BioMedicine (2017)
22. Assessment of Cervical Cancer Molecular-Based Screening Tools; Hpv-Dna Detection Versus E6/E7 Mrna Testing; First Report of a Prospective Cohort Study Among Iranian Women, Iranian Journal of Public Health (2020)
23. Anti-Tumor Activities of Probiotics in Cervical Cancer, Journal of Ovarian Research (2020)
24. Lineage Analysis of Human Papillomavirus Types 33 and 35 Based on E6 Gene in Cervical Samples From Tehran, Iran, Scientific Reports (2025)
25. Exploring the Intricacies of Cervical Intraepithelial Neoplasia and Its Connection With Hpv: A Narrative Review, Iranian Journal of Public Health (2024)
26. Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study From Iran, BioMed Research International (2022)
27. An Overview on Papillomaviruses As the Main Cause of Cervical Cancer, Iranian Journal of Obstetrics# Gynecology and Infertility (2015)
28. High Prevalence of Hpv-56 and Hpv-39 in Sari, Iran: An Analysis of Genotype Distribution, Virology Journal (2024)
29. Human Papilloma Virus Infection and Fascin Over-Expression in Squamous Cell Carcinoma of the Cervix, Medical Journal of the Islamic Republic of Iran (2018)
30. A Dual-Type L2 11-88 Peptide From Hpv Types 16/18 Formulated in Montanide Isa 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated With High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice, Journal of Immunology Research (2018)
31. Prophylactic Vaccines Against Hpv-Caused Cervical Cancer: Novel Vaccines Are Still Demanded, Infectious Agents and Cancer (2025)
32. Gender and Age-Specific Seroprevalence of Human Papillomavirus 16 and 18 in General Population in Tehran, Iran, Medical Microbiology and Immunology (2017)
33. Lineage and Sublineage Analysis of Human Papillomavirus Type 56 in Cervical Samples of Iranian Women, Journal of Medical Virology (2021)
34. Human Papillomavirus Status of Head and Neck Squamous Cell Carcinoma Patients and Its Association With Expression of Pik3ca and Crnde, Middle East Journal of Cancer (2021)
35. Critical Involvement of Circular Rnas in Virus-Associated Cancers, Genes and Diseases (2023)
36. Prevalence and Genotype Distribution of Human Papillomavirus in Individuals Referred to a Laboratory in Rey City, Iran, Discover Social Science and Health (2025)
37. Association Between Epstein-Barr Virus Infection and Gastric Cancer: A Systematic Review and Meta-Analysis, BMC Cancer (2020)
38. The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes, Jundishapur Journal of Microbiology (2016)
39. Epstein-Barr Virus and Risk of Breast Cancer: A Systematic Review and Meta-Analysis, Future Oncology (2019)
40. Lineage and Sublineage Analysis of Human Papillomavirus Types 51 and 59 in Iranian Women, Virus Genes (2024)
41. Detection and Typing of Human Papilloma Viruses by Nested Multiplex Polymerase Chain Reaction Assay in Cervical Cancer, Jundishapur Journal of Microbiology (2015)
42. The Prevalence of Hpv and Non-Hpv Stis Among Iranian Women and Assessment of the Hpv/Non-Hpv Stis Co-Infection on Cervical Cell Changes, Journal of Obstetrics# Gynecology and Cancer Research (2022)
43. Assessing Genetic Evolution and Detecting Human Papillomavirus by Matching Two Complementary Highly Sensitive Approaches, Nested-Qpcr and Sequencing, Infection# Genetics and Evolution (2020)
44. Lineages and Sublineages of Human Papillomavirus Type 16 in Cervical Samples of Iranian Women, Future Virology (2023)
45. Predictors of Pap Smear Screening Behavior Among Rural Women in Tabriz, Iran: An Application of Health Belief Model, International Journal of Cancer Management (2019)
46. Cancer Immunoprevention: Current Status and Future Directions, Archivum Immunologiae et Therapiae Experimentalis (2021)
47. Population Attributable Proportion and Number of Cancer Cases Attributed to Potentially Modifiable Risk Factors in Iran in 2020, International Journal of Cancer (2023)
48. Cervical Intraepithelial Neoplasia in Non-16/18 High-Risk Human Papilloma Virus Positive/Cytology Negative Women: An Alternative Approach in Poor Resource Areas, Taiwanese Journal of Obstetrics and Gynecology (2023)
49. Prevalence and Type Distribution of Human Papillomavirus Recovered From the Uterine Cervix of Nigerian Women: A Systematic Review and Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2020)
50. Cost-Effectiveness of Different Cervical Screening Strategies in Islamic Republic of Iran: A Middle-Income Country With a Low Incidence Rate of Cervical Cancer, PLoS ONE (2016)