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Comparison of Cytopathologic Findings in Patients With Negative Pap Test and Positive High-Risk Hpv Infection Among Three Groups Publisher Pubmed



Kasraei S1 ; Ghahghaeinezamabadi A1 ; Seifollahi A2 ; Aghajani F3 ; Nakhostinansari A4, 5 ; Zarei N1 ; Tehranian A1, 3
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Arash Women’s Hospital, Tehran University of Medical Sciences, Rashid Ave, Resalat Highway, Tehranpars, P.O Box: 1653915981, Tehran, Iran
  2. 2. Pathology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Development Center, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Sport Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Center for War-Affected People, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Gynecology and Obstetrics Published:2022


Abstract

Purpose: Comparison of colposcopy-guided biopsy and endocervical cytologic (ECC) results in patients with negative Papanicolaou (Pap) and positive high-risk (HR) HPV tests in the three groups of HPV 16/18, non-16/18 HR-HPV (other HR-HPV), and concurrent infection of either HPV 16/18 and at least one subtype of other HR-HPVs. Methods: This cross-sectional study was conducted among women aged 30–65 who had negative Pap and positive HR-HPV DNA tests. Pap test was performed using liquid cytology. For HPV DNA testing, the polymerase chain reaction (PCR) method was used. Results: Among 394 participants, 111 (28.2%) were in the HPV 16/18, 226 (57.4%) in the Other HR-HPV, and 57 (14.4%) in the concurrent group. The mean age of participants was 35.71 ± 7.1 years. Cervical intraepithelial neoplasia (CIN) grade 2/3 were seen in 29 (26.1%) patients of HPV 16/18, 60 (26.5%) of other HR-HPV, and 18 (31.6%) of concurrent infection group (P = 0.593). HPV 52 was the most common subtype in the other HR-HPV group (15%). Conclusions: The risk of high-grade CIN lesions in patients with negative Pap test and positive other HR-HPV was not significantly less than patients with positive HPV 16/18. Besides, the risk of losing the patients to 1-year follow-up seems high. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.