Association Study Between Functional Polymorphisms of Mmp9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population



Sabbagh S¹ ; Nadeali Z^{1, 2} ; Dehghani L³ ; Shaygannejad V¹ ; Rezvani M⁴ ; Saboori M⁴ ; Ganji H¹ ; Tahani S¹ ; Dehghani F¹ ; Hosseinzadeh S¹ ; Marzbani E¹ ; Shafiei P¹
Source: Iranian Journal of Public Health Published:2019

Abstract

Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C-1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS pa-tients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of -90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA re-peats, further research is needed before proposing any definite conclusion. © 2019, Iranian Journal of Public Health. All rights reserved.