The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials

The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials Publisher

Liu Y¹ ; Han F¹ ; Xia Z¹ ; Sun P² ; Rohani P³ ; Amirthalingam P⁴ ; Sohouli MH⁵

Show Affiliations

1. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
2. Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China
3. Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
5. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Diabetology and Metabolic Syndrome Published:2024

Abstract

Background: The global prevalence of obesity and overweight is a significant concern in the field of public health. However, addressing and combating these conditions pose considerable challenges. Numerous interventional studies have been conducted to assess the possible impact of bupropion on weight reduction. The primary objective of this study was to conduct a comprehensive investigation into the effects of bupropiona alone and in combination with naltrexone on weight, body mass index (BMI), and waist circumferences (WC). Methods: A systematic search was conducted in five databases using established keywords. The purpose of this search was to uncover controlled trials that examined the impact of bupropion, either as a standalone intervention or in combination with naltrexone, on weight loss outcomes. The random-effects model analysis was used to provide pooled weighted mean difference and 95% confidence intervals. Results: Twenty five studies with 22,165 participants’ were included in this article. The pooled findings showed that bupropion administration has an effect on lowering weight (WMD: -3.67 kg, 95% CI: -4.43 to -2.93) and WC (WMD: -2.98 cm, 95% CI -3.78 to -2.19) in compared with control groups. The analysis also showed that the effects of the present intervention on weight and WC during the intervention are > 26 weeks and ≤ 26 weeks compared to the other group, respectively. In addition, changes in weight loss and WC after receiving bupropion together with naltrexone were more compared to bupropion alone. Conclusions: In conclusion, the addition of combination therapies like bupropion and naltrexone to lifestyle modifications including diet would cause significant weight loss. © The Author(s) 2024.

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Style	Citing Format
MLA	Liu Y, et al.. "The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials." Diabetology and Metabolic Syndrome, vol. 16, no. 1, 2024, pp. -.
APA	Liu Y, Han F, Xia Z, Sun P, Rohani P, Amirthalingam P, Sohouli MH (2024). The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials. Diabetology and Metabolic Syndrome, 16(1), -.
Chicago	Liu Y, Han F, Xia Z, Sun P, Rohani P, Amirthalingam P, Sohouli MH. "The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials." Diabetology and Metabolic Syndrome 16, no. 1 (2024): -.
Harvard	Liu Y et al. (2024) 'The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials', Diabetology and Metabolic Syndrome, 16(1), pp. -.
Vancouver	Liu Y, Han F, Xia Z, Sun P, Rohani P, Amirthalingam P, et al.. The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials. Diabetology and Metabolic Syndrome. 2024;16(1):-.
BibTex	@article{ author = {Liu Y and Han F and Xia Z and Sun P and Rohani P and Amirthalingam P and Sohouli MH}, title = {The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials}, journal = {Diabetology and Metabolic Syndrome}, volume = {16}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Liu Y AU - Han F AU - Xia Z AU - Sun P AU - Rohani P AU - Amirthalingam P AU - Sohouli MH TI - The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials JO - Diabetology and Metabolic Syndrome VL - 16 IS - 1 SP - EP - PY - 2024 ER -

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