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Mycosis Fungoides Two Decades After Exposure to Sulphur Mustard: A Follow-Up of 1100 Victims Publisher Pubmed



Emadi SN1 ; Shiri M1 ; Shiri Z2 ; Emadi SE3 ; Mortazavi H1 ; Nikoo A4 ; Akhavanmoghaddam J5
Authors
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Authors Affiliations
  1. 1. Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Arts and Architecture, Islamic Azad University, Tehran, Iran
  3. 3. Mazandaran University of Medical Sciences, Mazandaran, Iran
  4. 4. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of General Surgery, Baqiyatallah University of Iran, Tehran, Iran

Source: Journal of the European Academy of Dermatology and Venereology Published:2017


Abstract

Background: Sulphur mustard (SM) is an alkylating chemical warfare agent which causes acute and chronic injuries to the eyes, skin, lung and respiratory tract. Objective: We aimed to investigate the relationship between SM poisoning and Mycosis fungoides (MF) as a late consequence. Material and Methods: In this retrospective study, the medical files of 1100 Iranian veterans confirmed to have exposure to SM agent during the Iraq–Iran war of the 1980s were reviewed. Results: All 10 cases with MF were confirmed by clinical and histopathological examinations. The mean age of the studied subjects was 43.3 ± 9.8 (years). In comparison to MF incidence rate in Iranian general population (0.39/100 000 person-years), we found an incidence rate of 0.799/100 000 person-years for MF among those who had short-term exposure to SM. The most common sites for SM lesions were flexural and thin skin areas. The main limitation was the retrospective design. Conclusion: This study indicates that the risk of MF in those exposed to SM may increase over time. Therefore, their follow-up is recommended. © 2016 European Academy of Dermatology and Venereology