Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Most Up-To-Date Advancements in the Design and Development of Urease Inhibitors (January 2020-March 2024) Publisher Pubmed



Babaei D1 ; Saeedian Moghadam E2 ; Navidpour L1 ; Amini M1, 2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Journal of Agricultural and Food Chemistry Published:2025


Abstract

The aim of this review is to address the most up-to-date information on the design and development, structure-activity relationship (SAR), and molecular docking study of novel and effective urease inhibitors between January 2020 and March 2024. Herein, the importance of the substituents and their effect on bioactivity of the reported compounds have been investigated. Besides, the relation between the most important residues inside the active site of the urease enzyme for interactions of the inhibitors and the active site of the enzyme has also been reviewed. This review has been classified into main reported scaffolds, namely, barbiturates, thiobarbiturates, Schiff bases, semicarbazides, thiosemcarbazides, benzimidazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles, to provide better insight into the newly developed urease inhibitors. © 2025 American Chemical Society.
Related Docs
1. Design and Synthesis of New N-Thioacylated Ciprofloxacin Derivatives As Urease Inhibitors With Potential Antibacterial Activity, Scientific Reports (2022)
2. Piperazine-Based Semicarbazone Derivatives As Potent Urease Inhibitors: Design, Synthesis, and Bioactivity Screening, Letters in Drug Design and Discovery (2022)
3. Different Barbiturate Derivatives Linked to Aryl Hydrazone Moieties As Urease Inhibitors; Design, Synthesis, Urease Inhibitory Evaluations, and Molecular Dynamic Simulations, Medicinal Chemistry Research (2023)
4. Design, Synthesis, in Vitro, and in Silico Investigations of New Barbituric Acid-Hydrazone-Chalcone Derivatives As Promising Urease Inhibitors, Journal of Molecular Structure (2025)
5. Design, Synthesis, in Vitro Evaluation, and Molecular Dynamics Simulation Studies of Novel Coumarin-Acetohydrazide Schiff Base Derivatives As Urease Enzyme Inhibitors, Medicinal Chemistry Research (2025)
6. Novel Coumarin-Based Acetohydrazide-1,2,3-Triazole Derivatives As Urease Enzyme Inhibitors: Synthesis, in Vitro Evaluation, and Molecular Dynamics Simulation Studies, Heliyon (2025)
7. [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole Derivatives As New Therapeutic Candidates Against Urease Positive Microorganisms: Design, Synthesis, Pharmacological Evaluations, and in Silico Studies, Scientific Reports (2023)
8. Design and Synthesis of Novel Nitrothiazolacetamide Conjugated to Different Thioquinazolinone Derivatives As Anti-Urease Agents, Scientific Reports (2022)
Experts (# of related papers)
View all Related Experts
Massoud Amanlou (7)
Mohammad Mahdavi (7)