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Polycystic Ovary Syndrome Pcos and Depression Role of Neuroinflammation Publisher



Mr Ramezanpour Mohammad REZA ; O Bahrami OMID ; Muhammad Parsa PASHAZADEH ; R Sarallah ROJIN ; R Nikfar REZA ; M Majidi Zolbin MASOUMEH
Authors

Source: Published:2025


Abstract

Polycystic ovary syndrome (PCOS) is a multidimensional condition with metabolic, hormonal, and neuropsychiatric effects. Depression is common among PCOS patients, and emerging research shows neuroinflammation as a probable reason. Chronic low- grade inflammation, insulin resistance, hyperandrogenism, and gut dysbiosis all contribute to neuroinflammatory processes, which result in hypothalamic dysfunction, neurotransmitter imbalances, and hypothalamic- pituitary- adrenal (HPA) axis dysregulation. Abnormal microglial activation and oxidative stress may further damage neuroplasticity, interfering with proper mood regulation. This chapter investigates how neuroinflammatory pathways influence the relationship between PCOS and depression, focusing on their effects on brain function and mood regulation. This chapter addresses neuroinflammation as a mechanism contributing to psychiatric symptoms in PCOS by identifying key inflammatory drivers, as well as prospective treatment targets. © 2025 Elsevier B.V., All rights reserved.
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