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Gut Microbiota: A Perspective of Precision Medicine in Endocrine Disorders Publisher



Shirvani Rad S1, 2 ; Nikkhah A3 ; Orvatinia M3 ; Ejtahed HS4, 5 ; Sarhangi N2 ; Jamaldini SH6 ; Khodayari N7 ; Aghaei Meybodi HR2 ; Hasanzad M2, 6
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  7. 7. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States

Source: Journal of Diabetes and Metabolic Disorders Published:2020


Abstract

Gut microbiota composition is unique in every individual, it impacts on organ functions that produce hormones. Gut microbiota composition balance is directly related to our general health status. This continual interaction between gut microbiota and endocrine organs sometimes can be considered as the etiology of diseases such as type 2 diabetes mellitus (T2DM), obesity, osteoporosis, polycystic ovary syndrome (PCOS), and thyroid diseases. Microbiota is introduced for a total collection of microbial organisms in our bodies and microbiome referred for their genome and their collective functions. Near 100 trillion microorganisms live in our body and almost all of them occupy the human gut gastrointestinal tract. Precision medicine can play a crucial role in health maintenance by affecting gut microbiota composition in every individual. It can also develop special treatments specifically for every individual. In this review, we addressed any correlation between gut microbiota and endocrine disorders including T2DM, obesity, PCOS, thyroid disorders and osteoporosis. © 2020, Springer Nature Switzerland AG.
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