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Modulating Pro-Inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury With Subventricular Zone-Derived Extracellular Vesicles Publisher Pubmed



Ijaz S1 ; Mohammed I1 ; Gholaminejhad M1 ; Mokhtari T2, 3 ; Akbari M1 ; Hassanzadeh G1
Authors
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Authors Affiliations
  1. 1. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China
  3. 3. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China

Source: Journal of Molecular Neuroscience Published:2020


Abstract

Background: The upregulation of TNF-α, IL-1β, IL-18, and IL-6 exacerbates the spinal cord injury by amplifying the neuroinflammation. Impeding the release and activation of these cytokines can stop the progression of lesion and promote healing. Modulating the inflammatory response with subventricular zone-derived extracellular vesicles (SVZ-EVs) is one highly promising approach. Methods and materials: SVZ tissue was cultured and EVs were prepared, isolated, and injected intrathecal, in spinal cord-injured (SCI) rats. BBB locomotor scoring, qRT-PCR, Western Blot, H&E, and Nissl staining techniques were applied to record the outcomes. Results: The intracisternally injected SVZ-EVs significantly decreased the gene and protein expression of TNF-α, IL-1β, IL-18, and IL-6, prevented extensive tissue damage, allowed healing, and improved the hind limb motor function in SCI models. Conclusion: The results of the present study showed that SVZ-EVs therapy ameliorate inflammation, tissue damage, and motor deficit in traumatic spinal cord injury. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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