Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Long Non-Coding Rnas (Lncrnas); Roles in Tumorigenesis and Potentials As Biomarkers in Cancer Diagnosis Publisher Pubmed



Najafi S1 ; Khatami SH2 ; Khorsand M3 ; Jamali Z4 ; Shabaninejad Z5 ; Moazamfard M6 ; Majidpoor J7 ; Aghaei Zarch SM8 ; Movahedpour A6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  7. 7. Department of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
  8. 8. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Experimental Cell Research Published:2022


Abstract

New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a broad range of biological processes, including the pathogenesis of many complex human diseases, including cancer. The detailed regulation mechanisms of many lncRNAs in cancer initiation and progression have yet to be discovered, even though a few of lncRNAs’ functions in cancer have been characterized. In the present study, we summarize recent advances in the mechanisms and functions of lncRNAs in cancer. We focused on the roles of newly-identified lncRNAs as oncogenes and tumor suppressors, as well as the potential pathways these molecules could play. The paper also discusses their potential uses as biomarkers for the diagnosis and prognosis of cancer. © 2022 Elsevier Inc.
Related Docs
View other Related Docs
1. Lncrna Involvement in Hepatocellular Carcinoma Metastasis and Prognosis, EXCLI Journal (2018)
2. Role of Non-Coding Rnas As New Therapeutic Targets in Regulating the Emt and Apoptosis in Metastatic Gastric and Colorectal Cancers, Cell Cycle (2023)
3. Long Noncoding Rnas Biomarker-Based Cancer Assessment, Journal of Cellular Physiology (2019)
4. Autophagy and Gastrointestinal Cancers: The Behind the Scenes Role of Long Non-Coding Rnas in Initiation, Progression, and Treatment Resistance, Cancer Gene Therapy (2021)
5. An Overview of Long Noncoding Rnas: Biology, Functions, Therapeutics, Analysis Methods, and Bioinformatics Tools, Cell Biochemistry and Function (2022)
6. Lncrnas Roles in Chemoresistance of Cancer Cells, Current Molecular Medicine (2022)
7. A Systematic Review of Long Non-Coding Rnas With a Potential Role in Breast Cancer, Mutation Research - Reviews in Mutation Research (2021)
8. Modulation of Long Non-Coding Rnas by Resveratrol As a Potential Therapeutic Approach in Cancer: A Comprehensive Review, Pathology Research and Practice (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (5)
Ehsan Khalili (4)
Other Related Docs
9. Regulation of Long Non-Coding Rnas by Plant Secondary Metabolites: A Novel Anticancer Therapeutic Approach, Cancers (2021)
10. Lncrna Malat1 As Diagnostic and Prognostic Biomarker in Colorectal Cancers: A Systematic Review and Meta-Analysis, PLoS ONE (2024)
11. Targeting Long Noncoding Rnas in Neuroblastoma: Progress and Prospects, Chemical Biology and Drug Design (2023)
12. Exosomal Long Non-Coding Rnas: Novel Molecules in Gastrointestinal Cancers’ Progression and Diagnosis, Frontiers in Oncology (2022)
13. Metformin and Long Non-Coding Rnas in Breast Cancer, Journal of Translational Medicine (2023)
14. Exploring the Therapeutic Potential of Quercetin in Cancer Treatment: Targeting Long Non-Coding Rnas, Pathology Research and Practice (2024)
15. Virus, Exosome, and Microrna: New Insights Into Autophagy, Advances in Experimental Medicine and Biology (2022)
16. Non-Coding Rnas: Emerging Contributors to Chemoresistance in Chronic Myeloid Leukemia, Leukemia Research Reports (2025)
17. The Significance of Exosomal Non-Coding Rnas (Ncrnas) in the Metastasis of Colorectal Cancer and Development of Therapy Resistance, Gene (2025)
18. Cdkn2b-As1 As a Novel Therapeutic Target in Cancer: Mechanism and Clinical Perspective, Biochemical Pharmacology (2023)
19. Long Noncoding Rnas and Exosomal Lncrnas: Classification, and Mechanisms in Breast Cancer Metastasis and Drug Resistance, Oncogene (2020)
20. Potential Roles of Lncrna-Xist/Mirnas/Mrnas in Human Cancer Cells, Clinical and Translational Oncology (2023)
21. Modulation of Cancer Cell Signaling by Long Noncoding Rnas, Journal of Cellular Biochemistry (2019)
22. To Be or Not to Be: Navigating the Influence of Micrornas on Cervical Cancer Cell Death, Cancer Cell International (2025)
23. Expression of Long Non-Coding Rna H19 in Acute Lymphoblastic Leukemia, Cell Journal (2023)
24. Constructing Mrna, Mirna, Circrna and Lncrna Regulatory Network by Analysis of Microarray Data in Breast Cancer, Gene Reports (2022)
25. A Comprehensive Insight Into the Correlation Between Ncrnas and the Wnt/Β-Catenin Signalling Pathway in Gastric Cancer Pathogenesis, Cell Communication and Signaling (2023)
26. The Emerging Role of Lncrnas in Multiple Sclerosis, Journal of Neuroimmunology (2020)
27. Identification of Key Lncrnas Associated With Oxaliplatin Resistance in Colorectal Cancer Cells and Isolated Exosomes: From In-Silico Prediction to In-Vitro Validation, PLoS ONE (2024)
28. The Role of Noncoding Rnas in Pituitary Adenoma, Epigenomics (2021)
29. Tracing Vitamins on the Long Non-Coding Lane of the Transcriptome: Vitamin Regulation of Lncrnas, Genes and Nutrition (2024)
30. The Role of Curcumin in Modulating Circular Rnas and Long Non-Coding Rnas in Cancer, Clinical and Translational Oncology (2025)
31. A Comprehensive Review of the Role of Lncrnas in Gastric Cancer (Gc) Pathogenesis, Immune Regulation, and Their Clinical Applications, Pathology Research and Practice (2023)
32. Critical Role of the Long Non-Coding Rnas (Lncrnas) in Radiotherapy (Rt)-Resistance of Gastrointestinal (Gi) Cancer: Is There a Way to Defeat This Resistance?, Pathology Research and Practice (2024)
33. Exosomal Micrornas and Long Noncoding Rnas: Novel Mediators of Drug Resistance in Lung Cancer, Journal of Cellular Physiology (2022)
34. Competing Endogenous Rnas Regulatory Crosstalk Networks: The Messages From the Rna World to Signaling Pathways Directing Cancer Stem Cell Development, Heliyon (2024)
35. Evaluation of the Expression Level of Some Coding and Non-Coding Genes in Breast Cancer Samples Based on Bioinformatics and Laboratory Studies, International Journal of Cancer Management (2024)
36. Non-Coding Rna in the Regulation of Gastric Cancer Tumorigenesis: Focus on Micrornas and Exosomal Micrornas, International Journal of Molecular and Cellular Medicine (2024)
37. Hotair Long Noncoding Rna Is Not a Biomarker for Acute Myeloid Leukemia (Aml) in Iranian Patients, Asian Pacific Journal of Cancer Prevention (2017)
38. Applications of Resveratrol in the Treatment of Gastrointestinal Cancer, Biomedicine and Pharmacotherapy (2022)
39. Expression Analysis of Long Non-Coding Rnas Related With Foxm1, Gata3, Foxa1 and Esr1 in Breast Tissues, Frontiers in Oncology (2021)
40. Exosomal Noncoding Rnas in Prostate Cancer, Clinica Chimica Acta (2022)
41. Long Non-Coding Rnas in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-Of-The-Art Review, Frontiers in Oncology (2021)
42. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
43. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)
44. Long Non-Coding Rnas and Melanoma: From Diagnosis to Therapy, Pathology Research and Practice (2023)
45. Targeting Epigenetics in Cancer: Therapeutic Potential of Flavonoids, Critical Reviews in Food Science and Nutrition (2021)
46. Distinct Gene Expression Patterns of Sox2 and Sox2ot Variants in Different Types of Brain Tumours, Journal of Genetics (2023)
47. The Microrna Let-7 and Its Exosomal Form: Epigenetic Regulators of Gynecological Cancers, Cell Biology and Toxicology (2024)
48. Anti-Differentiation Non-Coding Rna, Ancr, Is Differentially Expressed in Different Types of Brain Tumors, Journal of Neuro-Oncology (2018)
49. Transcript-Level Regulation of Malat1-Mediated Cell Cycle and Apoptosis Genes Using Dual Mek/Aurora Kinase Inhibitor “Bi-847325” on Anaplastic Thyroid Carcinoma, DARU# Journal of Pharmaceutical Sciences (2019)
50. Tumor-Derived Urinary Exosomal Long Non-Coding Rnas As Diagnostic Biomarkers for Bladder Cancer, EXCLI Journal (2020)