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Hematologic Predictors of Mortality in Hospitalized Patients With Covid-19: A Comparative Study Publisher Pubmed



Mousavi SA1 ; Rad S1 ; Rostami T1 ; Rostami M1 ; Mousavi SA1 ; Mirhoseini SA1 ; Kiumarsi A1
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Authors Affiliations
  1. 1. Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Hematology (United Kingdom) Published:2020


Abstract

Background: The first cases of proved COVID-19 in Iran were reported in February 2020 and has since rapidly spread worldwide. We aimed to clarify the clinical significance of hematologic parameters alteration in COVID-19. Methods: Different hematologic parameters were measured in 225 hospitalized COVID-19 patients in a tertiary care university hospital, during the peak of COVID-19 outbreak and their association with duration of hospitalization, ICU admission and especially mortality was analyzed. Results: Among a total of 225 patients, 24.4% did not survive after admission. Lymphopenia and neutrophilia were observed in 52.7% and 21.4% of the patients, respectively. The mean count of neutrophils was significantly higher in non-survived patients (P =.032). Elevated neutrophil-to-lymphocyte ratio (NLR) was significantly associated with mortality (P <.001). Low hemoglobin (Hb) concentration significantly correlated with mortality (P =.004) and ICU admission (P =.04). Platelet (Plt) count was significantly lower in the non-survived patients (P =.023). Non-survivors had significantly lower nadir Hb and Plt counts than survivors (P <.001 in both parameters). Platelet-to-lymphocyte ratio (PLR) also correlated with mortality and was significantly higher in non-survivors (P =.034). Conclusions: Hematologic laboratory parameters have always been a crucial component of diagnostic and therapeutic strategies in infectious disease. Hematologic predictors of a fatal outcome in COVID19 hospitalized patients in our series include elevated NLR and PLR, lower than normal Hb and Plt, elevated d-dimer and prolonged prothrombin time (PT), together with elevated inflammatory indicators in the blood. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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