Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units

Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units Publisher

Rafat Z¹ ; Ramandi A² ; Khaki PA³ ; Ansari S⁴ ; Ghaderkhani S⁵ ; Haidar H⁶ ; Tajari F⁷ ; Roostaei D⁸ ; Ghazvini RD⁹ ; Hashemi SJ⁹ ; Abdollahi A¹⁰ ; Kamali Sarvestani H⁹

Show Affiliations

1. Department of Medical Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2. Department of General Surgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Molecular Genetics, Faculty of Advanced Science and Technology, Islamic Azad University, Tehran, Iran
4. Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
6. School of Medicine, Marmara University, Istanbul, Turkey
7. Students' Scientific Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Department of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
9. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
10. Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, Iran

Source: Gene Reports Published:2022

Abstract

Backgrounds: The pandemic of COVID-19 has created a global public health crisis. ICU patients with COVID-19 are prone to infections of bacterial and/or fungal origins due to several risk factors. Consequently, the current study was conducted to evaluate the frequency, demographic characteristics, underlying conditions, and etiologic agents of fungal and bacterial co-infections of the respiratory tract among ICU patients with COVID-19 in Iran. Materials and methods: From May to October 2020, sputa and endotracheal aspirates were collected from ICU patients hospitalized with COVID-19 who also were suspected of bacterial and/or fungal co-infections according to inclusion criteria. The etiologic agents of bacterial co-infections were identified using the Vitek 2 identification method. For fungal identification, all samples were analyzed by direct microscopy using KOH 10% and culture. Furthermore, all isolates were subjected to sequencing method. Results: A total of 73 lung specimens were obtained from patients who met the inclusion criteria. Of these, in 15 cases (20.54%) fungal and/or bacterial co-infections were confirmed. Males were more infected (73.33%) and all of them were between 49 and 79 years. Candida albicans (n = 8, 61.53%) and Klebsiella pneumoniae (n = 5, 38.46%) were the most frequent etiologic agents related to fungal and bacterial co-infections, respectively. Pneumonia (n = 15, 100%) and diabetes mellitus (n = 8, 53.33%) were documented as the most prevalent underlying conditions. In the current study, 3 out of 15 patients (20%) died. Conclusion: The frequency of bacterial co-infections of the respiratory tract in ICU patients hospitalized with COVID-19 was relatively high. According to the results, one of the causes of death of these patients could be a secondary infection. © 2022

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Style	Citing Format
MLA	Rafat Z, et al.. "Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units." Gene Reports, vol. 27, no. , 2022, pp. -.
APA	Rafat Z, Ramandi A, Khaki PA, Ansari S, Ghaderkhani S, Haidar H, Tajari F, Roostaei D, Ghazvini RD, Hashemi SJ, Abdollahi A, Kamali Sarvestani H (2022). Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units. Gene Reports, 27(), -.
Chicago	Rafat Z, Ramandi A, Khaki PA, Ansari S, Ghaderkhani S, Haidar H, Tajari F, et al.. "Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units." Gene Reports 27, no. (2022): -.
Harvard	Rafat Z et al. (2022) 'Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units', Gene Reports, 27(), pp. -.
Vancouver	Rafat Z, Ramandi A, Khaki PA, Ansari S, Ghaderkhani S, Haidar H, et al.. Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units. Gene Reports. 2022;27():-.
BibTex	@article{ author = {Rafat Z and Ramandi A and Khaki PA and Ansari S and Ghaderkhani S and Haidar H and Tajari F and Roostaei D and Ghazvini RD and Hashemi SJ and Abdollahi A and Kamali Sarvestani H}, title = {Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units}, journal = {Gene Reports}, volume = {27}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Rafat Z AU - Ramandi A AU - Khaki PA AU - Ansari S AU - Ghaderkhani S AU - Haidar H AU - Tajari F AU - Roostaei D AU - Ghazvini RD AU - Hashemi SJ AU - Abdollahi A AU - Kamali Sarvestani H TI - Fungal and Bacterial Co-Infections of the Respiratory Tract Among Patients With Covid-19 Hospitalized in Intensive Care Units JO - Gene Reports VL - 27 IS - SP - EP - PY - 2022 ER -

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