Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Potential Role of Chitosan-Based Nanoparticles As Drug Delivery Systems in Pancreatic Cancer Publisher Pubmed



Sadoughi F1 ; Mansournia MA2 ; Mirhashemi SM3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran

Source: IUBMB Life Published:2020


Abstract

Pancreatic cancer (PC) is one of the most lethal cancers and 12th most common cancer in the world. Due to the inaccessible anatomical position of the pancreas and asymptomatic early stages of this disease, PC has a high mortality rate. Therefore, providing reliable diagnostic and therapeutic tools are the keys to increase the PC survival rate. Nanotechnology is an inchoate field of science that previously scientists' tendency to enhance the efficacy of current preventive, diagnostic, and therapeutic methods has oriented them to build a bridge between this science and medicine. In the case of PC, nanotechnology suggests using drug delivery devices for a more effective and targeted therapy. Chitosan is a natural polymer that recently has attracted a lot of attention for being renewable, nontoxic, and bioabsorbable. In this article, we tend to look for the answer to this question: has nanotechnology been successful in using chitosan-based nanoformulations as carriers for preventing more individuals from suffering or at least increasing the 5-year survival of the PC patients?. © 2020 International Union of Biochemistry and Molecular Biology
Related Docs
View other Related Docs
1. Cervical Cancer and Novel Therapeutic and Diagnostic Approaches Using Chitosan As a Carrier: A Review, Current Pharmaceutical Design (2022)
2. Nanotechnology for Delivery of Gemcitabine to Treat Pancreatic Cancer, Biomedicine and Pharmacotherapy (2017)
3. Chitosan-Based Smart Stimuli-Responsive Nanoparticles for Gene Delivery and Gene Therapy: Recent Progresses on Cancer Therapy, International Journal of Biological Macromolecules (2024)
4. Microrna-155 and Its Exosomal Form: Small Pieces in the Gastrointestinal Cancers Puzzle, Cell Biology and Toxicology (2024)
5. Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery, AAPS PharmSciTech (2017)
6. Circular Rnas and Gastrointestinal Cancers: Epigenetic Regulators With a Prognostic and Therapeutic Role, Critical Reviews in Oncology/Hematology (2020)
7. Encapsulation for General Cancer Treatment, Principles of Biomaterials Encapsulation: Volume 2 (2023)
8. Optimization of Chitosan Nanoparticles As an Anti-Hiv Sirna Delivery Vehicle, International Journal of Biological Macromolecules (2019)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (2)
Farid Dorkoosh (2)
Other Related Docs
9. Biocidal Activity of Biodegradable Polymers, Biocidal Polymers (2019)
10. Uv Spectroscopy: A Novel Method for Determination of Degree of Substitution of Phthaloyl Group As Amine Protector in Chitosan, Zeitschrift fur Physikalische Chemie (2023)
11. Hypoxia Inducible Factors in the Tumor Microenvironment As Therapeutic Targets of Cancer Stem Cells, Life Sciences (2019)
12. In Vivo Drug Delivery of Gemcitabine With Pegylated Single-Walled Carbon Nanotubes, Materials Science and Engineering C (2016)
13. Targeting Sirna in Colorectal Cancer Therapy: Nanotechnology Comes Into View, Journal of Cellular Physiology (2019)
14. Chitosan-Grafted Graphene Materials for Drug Delivery in Wound Healing, Current Pharmaceutical Design (2025)
15. Tissue Engineered Skin Substitutes, Advances in Experimental Medicine and Biology (2018)
16. Identification of Potential Common Molecular Factors of Pancreatic Cancer and Diabetes Mellitus Using Microarray Data Analysis Combined With Bioinformatics Techniques and Experimental Validation, Biomedical and Biotechnology Research Journal (2021)
17. Investigation of Key Signaling Pathways and Appropriate Diagnostic Biomarkers Selection Between Non-Invasive to Invasive Stages in Pancreatic Cancer: A Computational Observation, Journal of Medicine and Life (2022)