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Ambient Air Pollution and Incident Cardiovascular Disease in People With Type 2 Diabetes Mellitus a Cohort Study Publisher Pubmed



Khajavi A1 ; Hashemimadani N2 ; Hassanvand MS3, 4 ; Naddafi K3, 4 ; Khamseh ME2
Authors
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Authors Affiliations
  1. 1. School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Center for Air Pollution Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Occupational and Environmental Medicine Published:2024


Abstract

Objectives: We aimed to assess the effect of air pollution on incident cardiovascular disease (CVD) in people with type 2 diabetes mellitus (T2DM). Methods: We tracked 486 T2DM patients from 2012 to 2021. Cox regression models were applied to assess the hazard of exposure to particulate matter, carbon monoxide (CO), ozone, nitrogen dioxide, and sulfur dioxide (SO2) on incident CVD, revealing hazard ratios (HRs). Results: CVD incidents occurred in 73 individuals. Among men, each 1-ppm increase in CO levels raised the risk of CVD (HR: 2.66, 95% CI: 1.30–5.44). For women, a 5-ppb rise in SO2 increased CVD risk (HR: 1.60, 95% CI: 1.11–2.30). No notable impact of particulate pollutants was found. Conclusions: Persistent exposure to gaseous air pollutants, specifically CO and SO2, is linked to the development of CVD in men and women with T2DM. © 2024 American College of Occupational and Environmental Medicine.
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