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Association Between Macrophage Migration Inhibitory Factor Gene Variation and Response to Glucocorticoid Treatment in Sudden Sensorineural Hearing Loss Publisher Pubmed



Yazdani N1 ; Kakavand Hamidi A2 ; Ghazavi H1 ; Rikhtegar MJ1 ; Motesadi Zarandi M1 ; Qorbani M3 ; Amoli MM2
Authors
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Authors Affiliations
  1. 1. Otorhinolaryngology Research Center, Amir-Alam Hospital, Department of Otolaryngology - Head and Neck Surgery, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Dr. Shariati Hospital, North Karegar St., Tehran, 14114, Iran
  3. 3. Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Audiology and Neurotology Published:2015


Abstract

Several lines of evidence suggest the role of the immune system in the pathogenesis of sudden sensorineural hearing loss (SSNHL). Macrophage migration inhibitory factor (MIF) mediates its role in various immune and inflammatory conditions by the regulation of immune reactions. Several studies have confirmed an association between MIF gene polymorphisms and susceptibility to various inflammatory and autoimmune disorders. The aim of this study was to explore the association between the MIF (-173 G/C) polymorphism (rs755622) and SSNHL in an Iranian population. In this case-control association study, SSNHL cases (n = 77) were included. Normal healthy subjects (n = 100) were also recruited from the same region. Genotyping for MIF (-173 G/C) polymorphism was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. The frequency of the MIF -173 C allele carriers (GC + CC genotype) was significantly elevated in SSNHL patients who responded to glucocorticoid treatment compared with the patients with no response to treatment. These results suggest that the MIF gene polymorphism is associated with a response to glucocorticoid treatment in patients with SSNHL. © 2015 S. Karger AG, Basel.