Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Clinical Aspects of Indirect Immunofluorescence for Autoimmune Diseases Publisher Pubmed



Ghanadan A1, 2, 3, 4, 5 ; Saghazadeh A3, 4 ; Jahanzad I1 ; Rezaei N3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pathology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, Razi Skin Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran

Source: Expert Review of Clinical Immunology Published:2015


Abstract

Because the most common term used in conversations considering autoimmunity is autoantibodies, it is well-expected that the indirect immunofluorescence assay, which detects antibodies directed against various antigens, is one of our most impressive techniques for investigating autoimmune diseases (AIDs). Roughly speaking, the current literature corroborates that this immunopathologic investigation means that autoantibodies detection makes a considerable contribution to both diagnostic and prognostic aspects of AIDs in the clinical setting. However, it varies between different AIDs, autoantibodies, ethnicities or detection methodologies. Directly focusing on the indirect immunofluorescence assay, we present evidence to support this multidimensional variation regarding the subject via reviewing briefly the best-investigated autoantibodies in the well-documented AIDs, including vasculitis, inflammatory bowel disease, scleroderma, autoimmune hepatitis, primary biliary cirrhosis, systemic lupus erythematosus and Sjogren's syndrome. © 2015 Informa UK, Ltd.
Related Docs
View other Related Docs
1. Autoimmune Diseases, Clinical Immunology (2022)
2. Epigenetic Alterations Underlying Autoimmune Diseases, Autoimmunity (2016)
3. Atherosclerosis and Autoimmunity: A Growing Relationship, International Journal of Rheumatic Diseases (2018)
4. Association Study Between Stat4 Polymorphisms and Susceptibility to Systemic Lupus Erythematosus Disease: A Systematic Review and Meta-Analysis, Meta Gene (2018)
5. Anti-Inflammatory Effects of Ivermectin in the Treatment Of Acetic Acid-Induced Colitis in Rats: Involvement of Gabab Receptors, Digestive Diseases and Sciences (2022)
6. Epigenetics of Autoimmune Diseases, Prognostic Epigenetics (2019)
7. Successful Treatment Strategies in Granulomatosis With Polyangiitis-Associated Peripheral Ulcerative Keratitis, Cornea (2016)
8. The Safety and Efficacy of Rituximab in Autoimmune Hepatitis: A Systematic Review and Quality Assessment, European Journal of Gastroenterology and Hepatology (2025)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (6)
Mahdi Mahmoudi (5)
Other Related Docs
9. Survivin and Autoimmunity; the Ins and Outs, Immunology Letters (2018)
10. A Wegner's Granulomatosis Risk Prediction Model Based on Machine Learning Algorithms, Journal of Biostatistics and Epidemiology (2023)
11. Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms in Autoimmune Hepatitis, Annals of Hepatology (2018)
12. Systemic Lupus Erythematosus Presenting With Finger Drop, Journal of Clinical and Diagnostic Research (2018)
13. Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis, Fetal and Pediatric Pathology (2019)
14. Occurance of Scleroderma-Sjogren Intermediate Phenotype and Addison’S Disease in a Patient: Case Report, Tehran University Medical Journal (2018)
15. Methyl-Cpg-Binding Protein 2 (Mecp2) Polymorphism in Iranian Patients With Systemic Lupus Erythematosus, Inflammation (2015)
16. Pd-1/Pd-L and Autoimmunity: A Growing Relationship, Cellular Immunology (2016)
17. Association of T Helper 1 Cytokine Gene Single Nucleotide Polymorphisms With Ulcerative Colitis and Crohn's Disease, Digestive Diseases (2018)
18. Potential Role of Viral Infection and B Cells As a Linker Between Innate and Adaptive Immune Response in Systemic Lupus Erythematosus, Immunologic Research (2021)
19. The Effect of Zinc Supplementation on Plasma C-Reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, European Journal of Pharmacology (2018)
20. Toll-Like Receptors in Inflammatory Bowel Disease: A Review of the Role of Phytochemicals, Phytomedicine (2024)