Decreased Sox2 Messenger Rna Expression in Basal Cell Carcinoma Publisher



Ahmadibeni R¹ ; Vandrajabpour F¹ ; Ahmadifard M¹ ; Daneshpazhooh M² ; Noormohammadpour P³ ; Rahmati J⁴ ; Hesari KK³ ; Yaseri M⁵ ; Tabrizi M¹ Show Affiliations
Source: Indian Journal of Dermatology Published:2020

Abstract

Background: Sox2, zeb1, and p21 have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated. We hypothesized BCC, contrary to SCC, and melanoma, could be a suitable model to study mechanisms which attenuate tumor metastasis. The aim of this study was to examine the messenger RNA (mRNA) expression levels of sox2, zeb1, and p21 in BCC. Materials and Methods: Twenty-seven nonmetastatic BCC and twelve normal skin samples were evaluated using real-time reverse transcriptase polymerase chain reaction. Results: The stemness marker sox2 demonstrated marked down-regulation, but zeb1 and p21 showed no significant change. Conclusions: Here, we report a negative association between sox2 mRNA expression level and nonmetastatic BCC, thus, providing a likely explanation for the fact that normal skin is more reliant on sox2 than BCC. BCC may be using decreased sox2 mRNA to remain incognito from metastatic potential. © 2020 Indian Journal of Dermatology | Published by Wolters Kluwer - Medknow.