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Treatment of Vitamin D Deficiency With High-Dose Vitamin D Supplementation and Its Effect on Hematological Indices in Pregnancy: A Secondary Analysis of a Randomized Clinical Trial



Rostami F1 ; Moghaddambanaem L2 ; Ghasemi N3 ; Hantoushzadeh S4
Authors
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Authors Affiliations
  1. 1. Dept. Of Medical Sciences, Islamic Azad University, Tehran medical sciences branch, Tehran, Iran
  2. 2. Dept. Of Midwifery & Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Dept. Of Medical science, Shahrood Branch, Islamic Azad University, Shahrood, Iran
  4. 4. Maternal Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Koomesh Published:2020

Abstract

Introduction: There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pregnant women with vitamin D deficiency. Materials and Methods: The present study was performed in October 2019 from a secondary and nonpredetermined analysis of the effect of vitamin D supplementation and comparison of serum vitamin D levels on blood parameters from a randomized controlled clinical trial. 215 pregnant mothers with vitamin D deficiency were entered in the study and were divided into two treatment groups of 50,000 units and 1000 units. Results: Mean serum levels of Hematocrit, Platelets, and Ferritin after treatment in the treatment groups with 50000 and 1000 unites were 38.6± 3.03 vs 36.05± 2.8 (P<0.38), 243083 ± 55302 vs 215942 ± 45513 (P<0.29) and 42.3± 33.5 vs 28.8± 21.7 (P<0.04), respectively. The mean Hemoglobin level in the treatment groups with 50,000 and 1000 units were 12.08± 1.17 vs. 12.3± 2.5 (P<0.84), respectively. In both groups, there was a significant relationship between serum vitamin D level, Hemoglobin and Hematocrit levels before treatment. (Respectively P<0.02, P<0.02 and P<0.05). The serum Ferritin level was significantly higher with serum vitamin D after treatment (P<0.04). Conclusion: This study showed that the results of two therapeutic groups in pregnant women with vitamin D deficiency, especially a dose of 50,000 units of vitamin D, compared to the first trimester of pregnancy, had different effects on the hematologic indices. © 2020, Semnan University of Medical Sciences. All rights reserved.
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