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The Interactive Effect of Vitamin D3 Supplementation and Vitamin D Receptor Polymorphisms on Weight and Body Composition in Overweight Women With Hypovitaminosis D: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Ebrahimof S1 ; Angoorani P2 ; Shabbidar S3 ; Abedidni S2 ; Jahangir F3 ; Hedayati M4
Authors
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Authors Affiliations
  1. 1. Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran
  2. 2. Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran
  3. 3. Department of Community Nutrition, Tehran University of Medical Sciences, School of Nutritional Sciences and Dietetics, Tehran, 1416643931, Iran
  4. 4. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 193954763, Iran

Source: Canadian Journal of Physiology and Pharmacology Published:2022


Abstract

Different responses to vitamin D supplementation may be due to genes involved in vitamin D metabolism, including the vitamin D receptor (VDR) gene. The present study aimed to determine the interactive effect of vitamin D supplementation and VDR polymorphisms, including FokI (rs2228570) and BsmI (1544410) on weight and body composition in overweight women with hypovitaminosis D. This study comprised two phases: a double-blind, randomized and a before-after clinical trial. In the first phase, 50 healthy overweight women aged 20–45 years with hypovitaminosis D were randomly categorized into intervention and control groups and were given 50 000 IU/w vitamin D3 or placebo for 12 weeks. In the second phase, 75 women received 50 000 IU/w of vitamin D3 for 12 weeks. All variables were measured at baseline and after 12 weeks. Circulating 25(OH)D was measured using an ELISA kit. Anthropometric indices were calculated according to standard protocol (WHO-TRH-854). Body composition was determined using the body impedance analysis method. The VDR polymorphisms were detected using the PCR sequence. Supplementation resulted in a significant increase in the level of 25(OH)D in the intervention group but did not affect the anthropometric profile of the subjects. When considering FokI genotypes, carriers of the FF genotype had higher fat mass reduction than carriers of Ff + ff genotypes. © 2022 The Author(s).
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