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In Vitro Cholinesterase Inhibitory Activity of Some Plants Used in Iranian Traditional Medicine Publisher Pubmed



Saeedi M1, 2 ; Babaie K3 ; Karimpourrazkenari E2 ; Vazirian M3 ; Akbarzadeh T2, 4 ; Khanavi M2, 3 ; Hajimahmoodi M2, 5 ; Shams Ardekani MR2, 3
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Pharmacy, Department of Pharmacognosy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Pharmacy, Department of Medicinal Chemistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Pharmacy, Department of Drug and Food Control, Tehran University of Medical Sciences, Tehran, Iran

Source: Natural Product Research Published:2017


Abstract

In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50 = 32.00 μg/mL) and anti-BChE (IC50 = 48.81 ± 0.1200 μg/mL) agent. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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