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Novel Indole-Isoxazole Hybrids: Synthesis and in Vitro Anti-Cholinesterase Activity Publisher



Vafadarnejad F1 ; Saeedi M2, 3 ; Mahdavi M4 ; Rafinejad A1 ; Karimpourrazkenari E3 ; Sameem B5 ; Khanavi M6 ; Akbarzadeh T1, 3
Authors

Source: Letters in Drug Design and Discovery Published:2017


Abstract

Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields. Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity. © 2017 Bentham Science Publishers.
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