Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Lineage and Sublineage Analysis of Human Papillomavirus Type 58 in Iranian Women Publisher Pubmed



Shabanpour M1 ; Jalalialhosseini P1 ; Shoja Z2 ; Ghafoorighahdarijani F1 ; Taherkhani S1 ; Jalilvand S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran
  2. 2. Department of Virology, Pasteur Institute of Iran, Tehran, Iran

Source: Virology Journal Published:2024


Abstract

Background: Variant analysis of distinct HPV types is important from different aspects including epidemiology, pathogenicity, and evolution. Methods: For this reason, the full sequence of the E6 and E7 genes of HPV 58 was examined in 130 HPV 58-infected cervical samples using PCR and sequencing. Results: Our results revealed that three lineages A, B, and D were found in this study; among which the B lineage was more common (91.50%). About sublineages, all samples of the B lineage belonged to the B1 sublineage, and samples that were classified as the A and D lineages were found to belong to the A1 (0.77%), A2 (5.38%), A3 (1.50%), and D2 (0.77%) sublineages. No statistically significant differences were found between lineages and stages of disease or amino acid changes (P > 0.05). Conclusion: Our results showed that lineage B, sublineage B1, was dominant in Iran. However, more studies with larger sample sizes from different parts of Iran are essential for assessing the pathogenicity risk of HPV 58 lineages in Iranian women with cervical cancer. © The Author(s) 2024.
Related Docs
View other Related Docs
1. Variant Analysis of Human Papillomavirus Type 52 in Iranian Women During 2018−2020: A Case-Control Study, Health Science Reports (2024)
2. Human Papillomavirus Type 16 Lineage Analysis Based on E6 Region in Cervical Samples of Iranian Women, Infection# Genetics and Evolution (2017)
3. Lineage and Sublineage Analysis of Human Papillomavirus Types 51 and 59 in Iranian Women, Virus Genes (2024)
4. Lineage Analysis of Human Papillomavirus Types 31 and 45 in Cervical Samples of Iranian Women, Journal of Medical Virology (2021)
5. Lineage Analysis of Human Papillomavirus Type 18 Based on E6 Region in Cervical Samples of Iranian Women, Journal of Medical Virology (2020)
6. Lineage Analysis of Human Papillomavirus Type 39 in Cervical Samples of Iranian Women, Virology Journal (2021)
7. The Lineage and Sublineage Investigation of Human Papillomavirus Type 16 in Tehran, Iran, During 2022–2023: A Cross-Sectional Study, Health Science Reports (2025)
8. Lineages and Sublineages of Human Papillomavirus Type 16 in Cervical Samples of Iranian Women, Future Virology (2023)
Experts (# of related papers)
View all Related Experts
Somayeh Jalilvand (22)
Shohreh Shahmahmoodi Sadeghi (3)
Other Related Docs
9. Lineage Analysis of Human Papillomavirus Types 33 and 35 Based on E6 Gene in Cervical Samples From Tehran, Iran, Scientific Reports (2025)
10. The Prevalence of Epstein-Barr Virus in Normal, Premalignant, and Malignant Uterine Cervical Samples in Iran, Intervirology (2024)
11. Lineage and Sublineage Analysis of Human Papillomavirus Type 56 in Cervical Samples of Iranian Women, Journal of Medical Virology (2021)
12. The Prevalence of Human Herpesvirus 8 in Normal, Premalignant, and Malignant Cervical Samples of Iranian Women, Virology Journal (2021)
13. Type-Specific Human Papillomavirus Prevalence in Cervical Intraepithelial Neoplasia and Cancer in Iran, Journal of Medical Virology (2018)
14. A Meta-Analysis of Human Papillomavirus Prevalence and Types Among Iranian Women With Normal Cervical Cytology, Premalignant Lesions, and Cervical Cancer, Journal of Medical Virology (2021)
15. Systematic Review and Meta-Analysis of Human Papillomavirus Prevalence and Types Among Women With Normal Cervical Cytology in the Eastern Mediterranean Region, Future Virology (2019)
16. Distribution of Human Papillomavirus Genotypes in Suspected Women Cytological Specimens From Tehran, Iran, Iranian Journal of Microbiology (2022)
17. Co‐Administration of 2’3’-Cgamp Sting Activator and Cpg-C Adjuvants With a Mutated Form of Hpv 16 E7 Protein Leads to Tumor Growth Inhibition in the Mouse Model, Infectious Agents and Cancer (2021)
18. Type-Specific Human Papillomavirus Prevalence in Iranian Women With Normal Cervical Cytology: The Impact of Current Hpv Vaccines, Intervirology (2018)
19. Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study From Iran, BioMed Research International (2022)
20. Meta-Analysis of Type-Specific Human Papillomavirus Prevalence in Iranian Women With Normal Cytology, Precancerous Cervical Lesions and Invasive Cervical Cancer: Implications for Screening and Vaccination, Journal of Medical Virology (2015)
21. A Meta-Analysis on Human Papillomavirus Type Distribution Among Women With Cervical Neoplasia in the Who Eastern Mediterranean Region, Intervirology (2019)
22. Xenotropic Murine Leukemia Virus-Related Virus and Rnase L R462q Variants in Iranian Patients With Sporadic Prostate Cancer, Iranian Red Crescent Medical Journal (2015)
23. Recalcitrant Cutaneous Warts in a Family With Inherited Icos Deficiency, Journal of Investigative Dermatology (2022)
24. The Prevalence of Human Papillomavirus Infection in Iranian Patients With Sinonasal Inverted Papilloma, Journal of the Chinese Medical Association (2016)
25. Discovering Tumor Microenvironment Dynamics in Hpv-Associated Cancers: Using Organoid-Based Models to Develop Therapeutics, Regenerative Engineering and Translational Medicine (2025)
26. Immunization of Mice by a Multimeric L2-Based Linear Epitope (17-36) From Hpv Type 16/18 Induced Cross Reactive Neutralizing Antibodies, Research in Pharmaceutical Sciences (2017)
27. Mitochondrial Haplogroups and Control Region Polymorphisms in Kaposi's Sarcoma Patients, Journal of Medical Virology (2015)
28. A Dual-Type L2 11-88 Peptide From Hpv Types 16/18 Formulated in Montanide Isa 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated With High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice, Journal of Immunology Research (2018)