T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development

T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development Publisher Pubmed

Bagheri N¹ ; Shirzad H¹ ; Mirzaei Y² ; Nahidsamiei M¹ ; Sanaei M¹ ; Rahimian G³ ; Shafigh M³ ; Zandi F⁴ ; Tahmasbi K⁵ ; Razavi A⁶

Show Affiliations

1. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Department of Biology, Faculty of Sciences, Soran University, Soran, Kurdistan Region, Iraq
3. Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4. Department of Medical Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5. Department of Pathology, Shahrekord University of Medical Sciences, Shahrekord, Iran
6. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Medical Research Published:2019

Abstract

Background: Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet+ cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection. Methods: A total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet+ cells were determined by immunohistochemistry. Results: The numbers of T-bet+ cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet+ cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet+ cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet+ cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD. Conclusion: Abnormal hyper-activation of T-bet+ cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions. © 2019 IMSS

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Style	Citing Format
MLA	Bagheri N, et al.. "T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development." Archives of Medical Research, vol. 50, no. 3, 2019, pp. 113-121.
APA	Bagheri N, Shirzad H, Mirzaei Y, Nahidsamiei M, Sanaei M, Rahimian G, Shafigh M, Zandi F, Tahmasbi K, Razavi A (2019). T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development. Archives of Medical Research, 50(3), 113-121.
Chicago	Bagheri N, Shirzad H, Mirzaei Y, Nahidsamiei M, Sanaei M, Rahimian G, Shafigh M, Zandi F, Tahmasbi K, Razavi A. "T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development." Archives of Medical Research 50, no. 3 (2019): 113-121.
Harvard	Bagheri N et al. (2019) 'T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development', Archives of Medical Research, 50(3), pp. 113-121.
Vancouver	Bagheri N, Shirzad H, Mirzaei Y, Nahidsamiei M, Sanaei M, Rahimian G, et al.. T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development. Archives of Medical Research. 2019;50(3):113-121.
BibTex	@article{ author = {Bagheri N and Shirzad H and Mirzaei Y and Nahidsamiei M and Sanaei M and Rahimian G and Shafigh M and Zandi F and Tahmasbi K and Razavi A}, title = {T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development}, journal = {Archives of Medical Research}, volume = {50}, number = {3}, pages = {113-121}, year = {2019} }
RIS	TY - JOUR AU - Bagheri N AU - Shirzad H AU - Mirzaei Y AU - Nahidsamiei M AU - Sanaei M AU - Rahimian G AU - Shafigh M AU - Zandi F AU - Tahmasbi K AU - Razavi A TI - T-Bet+ Cells Polarization in Patients Infected With Helicobacter Pylori Increase the Risk of Peptic Ulcer Development JO - Archives of Medical Research VL - 50 IS - 3 SP - 113 EP - 121 PY - 2019 ER -

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