Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Vitamin D Supplementation Up-Regulates Il-6 and Il-17A Gene Expression in Multiple Sclerosis Patients Publisher Pubmed



Naghavi Gargari B1 ; Behmanesh M1 ; Shirvani Farsani Z1 ; Pahlevan Kakhki M1 ; Azimi AR2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran
  2. 2. MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran

Source: International Immunopharmacology Published:2015


Abstract

Abstract Vitamin D regulates gene expression and affects target cell functions. IL-6 and IL-17A are pro-inflammatory cytokines associated with MS pathogenesis. The aim of this study was to investigate the vitamin D effects on the expression level of IL-6 and IL-17A in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients. Also, we performed a correlation analysis between the gene expression and some clinical features such as serum level of vitamin D and the expanded disability status scale (EDSS). Significant up-regulation of IL-6 and IL-17A gene expression was shown under vitamin D treatment. Also, some gender specific correlations between the gene expression with vitamin D levels were detected in female RR-MS patients. © 2015 Elsevier B.V.
Related Docs
View other Related Docs
1. Effect of Vitamin D Treatment on Interleukin-2 and Interleukin-4 Genes Expression in Multiple Sclerosis, Physiology and Pharmacology (2015)
2. Interleukin-10 But Not Transforming Growth Factor-Β1 Gene Expression Is Up-Regulated by Vitamin D Treatment in Multiple, Journal of the Neurological Sciences (2015)
3. The Expression of Vdr Mrna But Not Nf-Κb Surprisingly Decreased After Vitamin D Treatment in Multiple Sclerosis Patients, Neuroscience Letters (2017)
4. Ebv and Vitamin D Status in Relapsing-Remitting Multiple Sclerosis Patients With a Unique Cytokine Signature, Medical Microbiology and Immunology (2016)
5. Vitamin D Levels in Multiple Sclerosis Patients: Association With Tgf-Β2, Tgf-Βri, and Tgf-Βrii Expression, Life Sciences (2015)
6. The Expression of Lnc-Il-7R Long Non-Coding Rna Dramatically Correlated With Soluble and Membrane-Bound Isoforms of Il-7Ra Gene in Multiple Sclerosis Patients, Neuroscience Letters (2017)
7. The Correlation Between Plasma Levels of Vitamin D and Epigenetic Alterations of Treg-Specific Demethylated Region (Tsdr) in Rheumatoid Arthritis Patients, Acta Medica Iranica (2019)
8. Expression and Shedding of Cd44 in the Endometrium of Women With Endometriosis and Modulating Effects of Vitamin D: A Randomized Exploratory Trial, Journal of Steroid Biochemistry and Molecular Biology (2018)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (10)
Ali Akbar Sabour Yaraghi (5)
Other Related Docs
9. Immunomodulatory and Immunosuppressive Roles of 1Α,25(Oh)2D3 in Autoimmune Diseases, Scandinavian Journal of Immunology (2017)
10. Association of Two Polymorphisms in Msh2 and Xrcc1 Genes With Multiple Sclerosis in Iranian Population, Physiology and Pharmacology (2016)
11. Serum Vitamin D Level and Disease Activity in Patients With Recent Onset Rheumatoid Arthritis, International Journal of Rheumatic Diseases (2016)
12. A Randomized Controlled Trial on the Effect of Vitamin D3 on Inflammation and Cathelicidin Gene Expression in Ulcerative Colitis Patients, Saudi Journal of Gastroenterology (2016)
13. The Modulating Effects of Vitamin D on the Activity of Β-Catenin in the Endometrium of Women With Endometriosis: A Randomized Exploratory Trial, Gynecological Endocrinology (2021)
14. The Function of Epigenetic Processes in Multiple Sclerosis: Review Article, Tehran University Medical Journal (2020)
15. Hotair But Not Anril Long Non-Coding Rna Contributes to the Pathogenesis of Multiple Sclerosis, Immunology (2018)
16. Comparison of Follicular T Helper Cells, Monocytes, and T Cells Priming Between Newly Diagnosed and Rituximab-Treated Ms Patients and Healthy Controls, Research in Pharmaceutical Sciences (2022)
17. Ebv Infection and Vitamin D in Multiple Sclerosis Patients, Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis (2017)
18. Comparative Epigenetic Influence of Autologous Versus Fetal Bovine Serum on Mesenchymal Stem Cells Through in Vitro Osteogenic and Adipogenic Differentiation, Experimental Cell Research (2016)
19. Influence of Vitamins a and D on the Expression of Microrna27-3P Isoforms and Gata3 in Experimental Autoimmune Encephalomyelitis, Iranian Journal of Allergy# Asthma and Immunology (2022)
20. The Association of the Vitamin D Status With the Persistence of Anti-Hbs Antibody at 20 Years After Primary Vaccination With Recombinant Hepatitis B Vaccine in Infancy, Clinics and Research in Hepatology and Gastroenterology (2017)
21. Calcitriol, But Not Fgf23, Increases in Csf and Serum of Ms Patients, Journal of Neuroimmunology (2019)
22. The Association Analysis Between Rs1544410 and Rs10735810 Polymorphisms Located at Vdr Gene and Susceptibility to Multiple Sclerosis in Iranian Population, Gene Reports (2019)
23. The Putative Association of Tob1-As1 Long Non-Coding Rna With Immune Tolerance: A Study on Multiple Sclerosis Patients, NeuroMolecular Medicine (2020)
24. Iranian Consensus on Use of Vitamin D in Patients With Multiple Sclerosis, BMC Neurology (2016)
25. Anti-Inflammatory Effects of Atorvastatin by Suppressing Traf3ip2 and Il-17Ra in Human Glioblastoma Spheroids Cultured in a Three-Dimensional Model: Possible Relevance to Glioblastoma Treatment, Molecular Neurobiology (2018)
26. The Effect of Calcitriol and All-Trans Retinoic Acid on T-Bet, Ifn-Γ, Gata3 and Il-4 Genes Expression in Experimental Autoimmune Encephalomyelitis, APMIS (2020)
27. In Silico Analysis of Regulatory Elements of the Vitamin D Receptor, Baghdad Science Journal (2020)
28. Vitamin D Changes Expression of Dna Repair Genes in the Patients With Multiple Sclerosis, Gene (2021)
29. Dietary Fish Intake and the Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis of Observational Studies, Nutritional Neuroscience (2022)
30. Vitamin D Down-Regulates the Expression of Some Th17 Cell-Related Cytokines, Key Inflammatory Chemokines, and Chemokine Receptors in Experimental Autoimmune Encephalomyelitis, Nutritional Neuroscience (2019)
31. Vitamin D Decreases Cd40l Gene Expression in Ulcerative Colitis Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial, Turkish Journal of Gastroenterology (2020)
32. The Role of Lnc-Dc Long Non-Coding Rna and Socs1 in the Regulation of Stat3 in Coronary Artery Disease and Type 2 Diabetes Mellitus, Journal of Diabetes and its Complications (2018)
33. Vitamin D Increases Ctla-4 Gene Expression in Patients With Mild to Moderate Ulcerative Colitis, Middle East Journal of Digestive Diseases (2019)
34. Immunomodulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis Mice, a Multiple Sclerosis Animal Model, Iranian Journal of Allergy# Asthma and Immunology (2023)
35. Calcitriol for Oral Mucositis Prevention in Patients With Fanconi Anemia Undergoing Hematopoietic Sct: A Double-Blind, Randomized, Placebo-Controlled Trial, American Journal of Therapeutics (2016)
36. Lnc-Hnf1a-As1 and Its Target Gene Atg5 Is Dysregulated in Hla-Drb1*15:01-Negative Female Patients With Multiple Sclerosis, Gene Reports (2022)
37. Alteration of Ogg1, Myh and Mth1 Genes Expression in Relapsing-Remitting Multiple Sclerosis Patients, Physiology and Pharmacology (2017)
38. Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells, Health Biotechnology and Biopharma (2021)
39. A Systems Biology Approach for Mirna-Mrna Expression Patterns Analysis in Rheumatoid Arthritis, Combinatorial Chemistry and High Throughput Screening (2021)
40. Effects of Vitamin D Supplements on Frequency of Cd4+ T-Cell Subsets in Women With Hashimoto’S Thyroiditis: A Double-Blind Placebo-Controlled Study, European Journal of Clinical Nutrition (2019)
41. Epilepsy and Vitamin D: A Comprehensive Review of Current Knowledge, Reviews in the Neurosciences (2017)