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Phytochemical Investigation and Antifungal Activity of Daucus Littoralis Smith Sub Sp. Hyrcanicus Rech.F Publisher



Yousefbeyk F1 ; Golfakhrabadi F2 ; Amouei A3 ; Ghasemi S4 ; Amin M3 ; Gohari A2 ; Samadi N3 ; Amini M5 ; Amin G2
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Authors Affiliations
  1. 1. Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Guilan, 4194173774, Iran
  2. 2. Department of Pharmacognosy, Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  3. 3. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical, Tehran, 1417614411, Iran
  4. 4. Department of Medicinal Chemistry, School of Pharmacy, Guilan University of Medical Sciences, Guilan, 4194173774, Iran
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Research Journal of Phytochemistry Published:2015


Abstract

Daucus littoralis Smith subsp. hyrcanicus Rech.f. (Caspian carrot) is an endemic species in the north of Iran. The aim of this study was to report the separation and structural elucidation of constituents from the ethyl acetate extract of fruits, which have not been reported previously. A phenylpropanoid (myristicin), a sesquiterpenoid (acorenone B) and two fatty acids (palmitic and oleic acid) were identified by GC and GC/MS. Also acorenone B and triolein were isolated by different chromatographic methods and identified by 1H, 13C-NMR and MS spectra. Furthermore, the antifungal activity of the Fruits Ethyl Acetate (FEE) and Fruits Methanol Extracts (FME) were investigated against vulvovaginal isolates of Candida albicans. The results showed that both FEE and FME had antifungal activity for standard Candida (MIC 6.25 and 25 mg mL-1, respectively) as well as for the isolates with MIC ranged 25-100 mg mL-1. © 2015 Academic Journals Inc.
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