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Epigenetic Strategies to Boost Car T Cell Therapy Publisher Pubmed



Akbari B1 ; Ghahrisaremi N1 ; Soltantoyeh T1 ; Hadjati J1 ; Ghassemi S2 ; Mirzaei HR1
Authors

Source: Molecular Therapy Published:2021


Abstract

Chimeric antigen receptor (CAR) T cell therapy has led to a paradigm shift in cancer immunotherapy, but still several obstacles limit CAR T cell efficacy in cancers. Advances in high-throughput technologies revealed new insights into the role that epigenetic reprogramming plays in T cells. Mechanistic studies as well as comprehensive epigenome maps revealed an important role for epigenetic remodeling in T cell differentiation. These modifications shape the overall immune response through alterations in T cell phenotype and function. Here, we outline how epigenetic modifications in CAR T cells can overcome barriers limiting CAR T cell effectiveness, particularly in immunosuppressive tumor microenvironments. We also offer our perspective on how selected epigenetic modifications can boost CAR T cells to ultimately improve the efficacy of CAR T cell therapy. © 2021 The American Society of Gene and Cell Therapy
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