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Epigenetic Strategies to Boost Car T Cell Therapy Publisher Pubmed



Akbari B1 ; Ghahrisaremi N1 ; Soltantoyeh T1 ; Hadjati J1 ; Ghassemi S2 ; Mirzaei HR1
Authors
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Authors Affiliations
  1. 1. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  2. 2. Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, United States

Source: Molecular Therapy Published:2021


Abstract

Chimeric antigen receptor (CAR) T cell therapy has led to a paradigm shift in cancer immunotherapy, but still several obstacles limit CAR T cell efficacy in cancers. Advances in high-throughput technologies revealed new insights into the role that epigenetic reprogramming plays in T cells. Mechanistic studies as well as comprehensive epigenome maps revealed an important role for epigenetic remodeling in T cell differentiation. These modifications shape the overall immune response through alterations in T cell phenotype and function. Here, we outline how epigenetic modifications in CAR T cells can overcome barriers limiting CAR T cell effectiveness, particularly in immunosuppressive tumor microenvironments. We also offer our perspective on how selected epigenetic modifications can boost CAR T cells to ultimately improve the efficacy of CAR T cell therapy. © 2021 The American Society of Gene and Cell Therapy
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