Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters

Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters Publisher Pubmed

Kolahi Azar H^{1, 2} ; Imanpour A² ; Rezaee H^{2, 3} ; Ezzatifar F^{2, 4, 5} ; Zareibehjani Z^{2, 6} ; Rostami M^{7, 8} ; Azami M^{2, 9} ; Behestizadeh N^{2, 9} ; Rezaei N^{10, 11, 12}

Show Affiliations

1. Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
2. Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran
3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Molecular and Cell Biology Research Center, Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
6. Department of Tissue Engineering and Applied Cell Sciences, Advanced School of Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
7. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
8. Food Science and Nutrition Group (FSAN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
9. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
10. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
11. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
12. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: European Journal of Haematology Published:2024

Abstract

Mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)-T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molecules would primarily facilitate CAR-T cell trafficking into solid tumors. Multiple parameters affect cell homing, including the recipient's age, the number of cell passages, proper cell culture, and the delivery method. In addition, several chemokines are involved in the tumor microenvironment, affecting the homing procedure. This review discusses parameters that improve the efficiency of cell homing and significant cell therapy challenges. Emerging comprehensive mechanistic strategies such as non-systemic and systemic homing that revealed a significant role in cell therapy remodeling were also reviewed. Finally, the primary implications for the development of combination therapies that incorporate both MSCs and CAR-T cells for cancer treatment were discussed. © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Kolahi Azar H, et al.. "Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters." European Journal of Haematology, vol. 112, no. 2, 2024, pp. 153-173.
APA	Kolahi Azar H, Imanpour A, Rezaee H, Ezzatifar F, Zareibehjani Z, Rostami M, Azami M, Behestizadeh N, Rezaei N (2024). Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters. European Journal of Haematology, 112(2), 153-173.
Chicago	Kolahi Azar H, Imanpour A, Rezaee H, Ezzatifar F, Zareibehjani Z, Rostami M, Azami M, Behestizadeh N, Rezaei N. "Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters." European Journal of Haematology 112, no. 2 (2024): 153-173.
Harvard	Kolahi Azar H et al. (2024) 'Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters', European Journal of Haematology, 112(2), pp. 153-173.
Vancouver	Kolahi Azar H, Imanpour A, Rezaee H, Ezzatifar F, Zareibehjani Z, Rostami M, et al.. Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters. European Journal of Haematology. 2024;112(2):153-173.
BibTex	@article{ author = {Kolahi Azar H and Imanpour A and Rezaee H and Ezzatifar F and Zareibehjani Z and Rostami M and Azami M and Behestizadeh N and Rezaei N}, title = {Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters}, journal = {European Journal of Haematology}, volume = {112}, number = {2}, pages = {153-173}, year = {2024} }
RIS	TY - JOUR AU - Kolahi Azar H AU - Imanpour A AU - Rezaee H AU - Ezzatifar F AU - Zareibehjani Z AU - Rostami M AU - Azami M AU - Behestizadeh N AU - Rezaei N TI - Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters JO - European Journal of Haematology VL - 112 IS - 2 SP - 153 EP - 173 PY - 2024 ER -

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