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The Effect of Pegylated Iron Oxide Nanoparticles on Sheep Ovarian Tissue: An Ex-Vivo Nanosafety Study Publisher



Karimi S1 ; Tabatabaei SN2, 3 ; Gutleb AC4 ; Ghaffari Novin M1 ; Ebrahimzadehbideskan A5 ; Shams Mofarahe Z1
Authors
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Authors Affiliations
  1. 1. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pediatrics, Physiology and Pharmacology, University of Montreal, Montreal, QC, Canada
  4. 4. Department of Environmental Research and Innovation (ERIN), Luxembourg Institute of Science and Technology (LIST), Esch s/Alzette, Luxembourg
  5. 5. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Iran

Source: Heliyon Published:2020


Abstract

Today, nanotechnology plays an important role in our ever-continuous quest to improve the quality of human life. Because of their infinitesimal size, nanostructures can actively interact and alter cellular functions. Therefore, while the clinical benefits of nanotechnology may outweigh most of the associated risks, assessment of the cytotoxicity of nanostructures in respect to cells and tissues early in product development processes is of great significance. To the best of our knowledge, no such assessment has been performed for nanomaterials on the ovarian cortex before. Herein, silica-coated, PEGylated silica-coated, and uncoated iron oxide nanoparticles (IONP) with core diameter of 11 nm (±4.2 nm) were synthesized. The oxidative stress in cultured ovarian tissue exposed to the various IONP was subsequently assessed. The results indicate that among the four groups, uncoated IONP induce the most oxidative stress on the ovarian cortex while tissues treated with PEGylated IONP exhibit no significant change in oxidative stress. © 2020; Iron oxide nanoparticle, PEG, Silica, ovary, Oxidative Stress; Coatings; Materials Safety; Antioxidant; Lipid Peroxidation; Tissue Culture; Nanotechnology; Toxicology; Reproductive System. © 2020
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