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Nanowarming Improves Survival of Vitrified Ovarian Tissue and Follicular Development in a Sheep Model Publisher



Karimi S1, 4 ; Tabatabaei SN2, 3 ; Novin MG1 ; Kazemi M1 ; Mofarahe ZS1 ; Ebrahimzadehbideskan A4, 5
Authors
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Authors Affiliations
  1. 1. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pediatrics, Physiology and Pharmacology, University of Montreal, Qc, Montreal, Canada
  4. 4. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Iran
  5. 5. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Heliyon Published:2023


Abstract

Tissue cryopreservation has allowed long term banking of biomaterials in medicine. Ovarian tissue cryopreservation in particular helps patients by extending their fertility window. However, protection against tissue injury during the thawing process has proven to be challenging. This is mainly due to the heterogenous and slow distribution of the thermal energy across the vitrified tissue during a conventional warming process. Nanowarming is a technique that utilizes hyperthermia of magnetic nanoparticles to accelerate this process. Herein, hyperthermia of synthesized PEGylated silica-coated iron oxide nanoparticles was used to deter the injury of cryopreserved ovarian tissue in a sheep model. When compared to the conventional technique, our findings suggest that follicular development and gene expression in tissues warmed by the proposed technique have been improved. In addition, Nanowarming prevented cellular apoptosis and oxidative stress. We therefore conclude that Nanowarming is a potential complementary candidate to increase efficiency in the ovarian cryopreservation field. © 2023