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Highly Evolvable Malaria Vectors: The Genomes of 16 Anopheles Mosquitoes Publisher Pubmed



Neafsey DE1 ; Waterhouse RM2, 3, 4, 5 ; Abai MR6 ; Aganezov SS7 ; Alekseyev MA7 ; Allen JE8 ; Amon J9 ; Arca B10 ; Arensburger P11 ; Artemov G12 ; Assour LA13 ; Basseri H6 ; Berlin A1 ; Birren BW1 Show All Authors
Authors
  1. Neafsey DE1
  2. Waterhouse RM2, 3, 4, 5
  3. Abai MR6
  4. Aganezov SS7
  5. Alekseyev MA7
  6. Allen JE8
  7. Amon J9
  8. Arca B10
  9. Arensburger P11
  10. Artemov G12
  11. Assour LA13
  12. Basseri H6
  13. Berlin A1
  14. Birren BW1
  15. Blandin SA14, 15
  16. Brockman AI16
  17. Burkot TR17
  18. Burt A18
  19. Chan CS2, 3
  20. Chauve C19
  21. Chiu JC20
  22. Christensen M8
  23. Costantini C21
  24. Davidson VLM22
  25. Deligianni E23
  26. Dottorini T16
  27. Dritsou V24
  28. Gabriel SB25
  29. Guelbeogo WM26
  30. Hall AB27
  31. Han MV28
  32. Hlaing T29
  33. Hughes DST8, 30
  34. Jenkins AM31
  35. Jiang X27, 32
  36. Jungreis I2, 3
  37. Kakani EG33, 34
  38. Kamali M35
  39. Kemppainen P36
  40. Kennedy RC37
  41. Kirmitzoglou IK16, 38
  42. Koekemoer LL39
  43. Laban N40
  44. Langridge N8
  45. Lawniczak MKN16
  46. Lirakis M41
  47. Lobo NF42
  48. Lowy E8
  49. Maccallum RM16
  50. Mao C43
  51. Maslen G8
  52. Mbogo C44
  53. Mccarthy J11
  54. Michel K22
  55. Mitchell SN33
  56. Moore W45
  57. Murphy KA20
  58. Naumenko AN35
  59. Nolan T16
  60. Novoa EM2, 3
  61. Oloughlin S18
  62. Oringanje C45
  63. Oshaghi MA6
  64. Pakpour N46
  65. Papathanos PA16, 24
  66. Peery AN35
  67. Povelones M47
  68. Prakash A48
  69. Price DP49, 50
  70. Rajaraman A19
  71. Reimer LJ51
  72. Rokas A52, 53
  73. Russell TL17
  74. Sagnon N26
  75. Sharakhova MV35
  76. Shea T1
  77. Simao FA4, 5
  78. Simard F21
  79. Slotman MA54
  80. Somboon P55
  81. Stegniy V12
  82. Struchiner CJ56, 57
  83. Thomas GWC58
  84. Tojo M59
  85. Topalis P23
  86. Tubio JMC60
  87. Unger MF42
  88. Vontas J41
  89. Walton C36
  90. Wilding CS61
  91. Willis JH62
  92. Wu YC2, 3, 63
  93. Yan G64
  94. Zdobnov EM4, 5
  95. Zhou X53
  96. Catteruccia F33, 34
  97. Christophides GK16
  98. Collins FH42
  99. Cornman RS62
  100. Crisanti A16, 24
  101. Donnelly MJ51, 65
  102. Emrich SJ13
  103. Fontaine MC42, 66
  104. Hahn MW58, 67, 68
  105. Hansen IA49, 50
  106. Howell PI69
  107. Kafatos FC16
  108. Kellis M2, 3
  109. Lawson D8
  110. Louis C23, 24, 41
  111. Luckhart S46
  112. Muskavitch MAT31, 70
  113. Ribeiro JM71
  114. Riehle MA45
  115. Sharakhov IV27, 35
  116. Tu Z27, 32
  117. Zwiebel LJ72
  118. Besansky NJ42
Show Affiliations
Authors Affiliations
  1. 1. Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, 02142, MA, United States
  2. 2. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, 02139, MA, United States
  3. 3. Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, 02142, MA, United States
  4. 4. Department of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, Geneva, 1211, Switzerland
  5. 5. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, Geneva, 1211, Switzerland
  6. 6. Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, 20147, VA, United States
  8. 8. European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton, Cambridge, CB10 1SD, United Kingdom
  9. 9. National Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu
  10. 10. Department of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy
  11. 11. Department of Biological Sciences, California State Polytechnic-Pomona, 3801 West Temple Avenue, Pomona, 91768, CA, United States
  12. 12. Tomsk State University, 36 Lenina Avenue, Tomsk, Russian Federation
  13. 13. Department of Computer Science and Engineering, Eck Institute for Global Health, University of Notre Dame, 211B Cushing Hall, Notre Dame, 46556, IN, United States
  14. 14. Inserm, U963, Strasbourg, F-67084, France
  15. 15. CNRS, UPR9022, IBMC, Strasbourg, F-67084, France
  16. 16. Department of Life Sciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom
  17. 17. Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns, 4870, Australia
  18. 18. Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot, SL5 7PY, United Kingdom
  19. 19. Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, BC, Canada
  20. 20. Department of Entomology and Nematology, University of California-Davis, One Shields Avenue, Davis, 95616, CA, United States
  21. 21. Institut de Recherche Pour le Developpement, Unites Mixtes de Recherche Maladies Infectieuses et Vecteurs Ecologie, Genetique, Evolution et Controle, 911, Avenue Agropolis, Montpellier, BP 64501, France
  22. 22. Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, 66506, KS, United States
  23. 23. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100, Heraklion, Crete, GR-70013, Greece
  24. 24. Centre of Functional Genomics, University of Perugia, Perugia, Italy
  25. 25. Genomics Platform, Broad Institute, 415 Main Street, Cambridge, 02142, MA, United States
  26. 26. Centre National de Recherche et de Formation Sur le Paludisme, Ouagadougou 01, BP 2208, Burkina Faso
  27. 27. Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, 24061, VA, United States
  28. 28. School of Life Sciences, University of Nevada, Las Vegas, 89154, NV, United States
  29. 29. Department of Medical Research, No. 5 Ziwaka Road, Dagon Township, Yangon, 11191, Myanmar
  30. 30. Baylor College of Medicine, 1 Baylor Plaza, Houston, 77030, TX, United States
  31. 31. Boston College, 140 Commonwealth Avenue, Chestnut Hill, 02467, MA, United States
  32. 32. Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, 24061, VA, United States
  33. 33. Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, 02115, MA, United States
  34. 34. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universitadegli Studi di Perugia, Perugia, Italy
  35. 35. Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, 24061, VA, United States
  36. 36. Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
  37. 37. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 94143, CA, United States
  38. 38. Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, New Campus, Nicosia, 1678, CY, Cyprus
  39. 39. Faculty of Health Sciences, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa
  40. 40. National Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya
  41. 41. Department of Biology, University of Crete, Heraklion, 700 13, Greece
  42. 42. Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, 46556, IN, United States
  43. 43. Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, 1015 Life Science Circle, Blacksburg, 24061, VA, United States
  44. 44. Kenya Medical Research Institute, Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, P.O. Box 230-80108, Kilifi, Kenya
  45. 45. Department of Entomology, University of Arizona, 1140 East South Campus Drive, Forbes 410, Tucson, 85721, AZ, United States
  46. 46. Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, 95616, CA, United States
  47. 47. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, 19104, PA, United States
  48. 48. Regional Medical Research Centre NE, Indian Council of Medical Research, P.O. Box 105, Dibrugarh, 786 001, Assam, India
  49. 49. Department of Biology, New Mexico State University, Las Cruces, 88003, NM, United States
  50. 50. Molecular Biology Program, New Mexico State University, Las Cruces, 88003, NM, United States
  51. 51. Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, United Kingdom
  52. 52. Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, 37235, TN, United States
  53. 53. Department of Biological Sciences, Vanderbilt University, Nashville, 37235, TN, United States
  54. 54. Department of Entomology, Texas a AndM University, College Station, 77807, TX, United States
  55. 55. Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand
  56. 56. Fundac¸ao Oswaldo Cruz, Avenida Brasil 4365, RJ, Brazil
  57. 57. Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
  58. 58. School of Informatics and Computing, Indiana University, Bloomington, 47405, IN, United States
  59. 59. School of Medicine, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
  60. 60. Wellcome Trust Sanger Institute, Hinxton, St. Ives, CB10 1SA, United Kingdom
  61. 61. School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom
  62. 62. Department of Cellular Biology, University of Georgia, Athens, 30602, GA, United States
  63. 63. Department of Computer Science, Harvey Mudd College, Claremont, 91711, CA, United States
  64. 64. Program in Public Health, College of Health Sciences, University of California, Irvine, Hewitt Hall, Irvine, 92697, CA, United States
  65. 65. Malaria Programme, Wellcome Trust Sanger Institute, Cambridge, CB10 1SJ, United Kingdom
  66. 66. Centre of Evolutionary and Ecological Studies (Marine Evolution and Conservation Group), University of Groningen, Nijenborgh 7, NL-9747 AG, Groningen, Netherlands
  67. 67. Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, 02138, MA, United States
  68. 68. Department of Biology, Indiana University, Bloomington, 47405, IN, United States
  69. 69. Centers for Disease Control and Prevention, 1600 Clifton Road NE MSG49, Atlanta, 30329, GA, United States
  70. 70. Biogen Idec, 14 Cambridge Center, Cambridge, 02142, MA, United States
  71. 71. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Rockville, 20852, MD, United States
  72. 72. Departments of Biological Sciences and Pharmacology, Institutes for Chemical Biology, Genetics and Global Health, Vanderbilt University and Medical Center, Nashville, 37235, TN, United States

Source: Science Published:2015


Abstract

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ∼100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts. © 2015, american association for the advancement of science. All rigths reserved.