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Prognostic Factors for Survival After Allogeneic Transplantation in Acute Myeloid Leukemia in Iran Using Censored Quantile Regression Model Publisher Pubmed



Tatari M1 ; Kasaeian A2, 3, 4 ; Mousavian AH5, 6 ; Oskouie IM7 ; Yazdani A8, 9 ; Mousavi SA6 ; Zeraati H1 ; Yaseri M1
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Digestive Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Department of Biostatistics and Epidemiology, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran

Source: Scientific Reports Published:2025


Abstract

Hematopoietic stem cell transplantation (HSCT) emerged over sixty years ago as a groundbreaking and potentially curative treatment for patients with acute myeloid leukemia (AML) who were not responding to chemotherapy. In this study, we aimed to investigate prognostic factors for survival after allo-HSCT in AML patients. This retrospective cohort study was carried out using data from 742 adult AML patients underwent allo-HSCT. we analysis prognostic factors for survival after allo-HSCT with censored quantile regression model. The 5-year OS, DFS and GRFS rates were 58, 53, and 30%, respectively. OS for recipients older than 35 years was 0.95 and 1.12 years lower than that for recipients under 35 years in the 25th and 40th percentiles, respectively. Compared to patients in their CRІ, those with CRІІІ disease experienced a decrease in OS at the 25th and 40th percentiles by 1.72 and 3.72 years, respectively. Moreover, OS for ABO matched patients was 0.92 and 1.29 years longer than that of patients with an ABO major mismatch. This study could assist oncologists and hematologists in understanding the prognostic factors affecting patient survival across various survival ranges, thereby potentially extending patients’ lifespans. © The Author(s) 2025.
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