Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Historical Report on Preparing Sustained Release Dosage Forms for Addicts in Medieval Persia, 16Th Century Ad Publisher Pubmed



Soleymani S1, 2 ; Zargaran A2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of History of Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Substance Use and Misuse Published:2018


Abstract

For several centuries, opium addiction has been a social problem all over the world. It has been prevalent in Iran from the Safavid era (1501–1736 A.D). During this period, Hakim Imad al-Din Mahmud ibn-Mas'ud Shirazi (1515–1592 A.D), also known as Imad was one of the Persian physicians who wrote one of the earliest books in the field of opium and addiction (called Afiounieh) in history. In this book, he introduced two sustained release rectal (suppository) and oral (pill) dosage forms for Muslim addicts who fast in the month of Ramadan. He aimed to formulate them for these people so that they could keep fasting by using the slow release drugs. In these formulations, his innovation has important impacts in the history of both addiction and pharmaceutical sciences. © 2018, © 2018 Taylor & Francis Group, LLC.