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A Novel Sulfamic Acid Functionalized Nano-Catalyst on the Basis of Calix[4]Resorcinarene for the Green One-Pot Synthesis of 2H-Indazolo[2,1-B]Phthalazine-Triones Under Thermal Solvent-Free Conditions Publisher



Mouradzadegun A1, 2 ; Mostafavi MA1 ; Ganjali MR2, 3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Science, Shahid Chamran University, Ahvaz, Iran
  2. 2. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran
  3. 3. Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Reaction Kinetics# Mechanisms and Catalysis Published:2018


Abstract

N-propyl sulfamic acid supported nano-catalyst on the basis of calix[4]resorcinarene was prepared via the efficient and facile reaction of amine functionalized polycalix[4]resorcinarene with chlorosulfonic acid. The achieved catalytic system was characterized using some spectroscopic techniques such as Fourier transform Infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and CHNS elemental analysis. This newly developed acidic catalyst was employed efficiently in a one-pot three-component condensation reaction of aromatic aldehydes, dimedone and phthalhydrazide for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives through an easy and eco-friendly methodology. The catalyst was easily separated from the reaction mixture by simple filtration and the desired products were achieved in good to excellent yields in short reaction times. © 2018, Akademiai Kiado, Budapest, Hungary.