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Challenges of Using Sodium-Glucose Transporter-2 (Sglt-2) Inhibitors in the Treatment of Gestational Diabetes and Its Safety Considerations During Pregnancy



Bandarian M1 ; Bandarian F2, 3
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Diabetes and Metabolism Published:2023

Abstract

Sodium-glucose transporter-2 (SGLT-2) inhibitors are a relatively new class of anti-diabetic drugs with potent effect in glycemic control and weight loss, as well as beneficial effects in the prevention and control of cardiac and renal complications in non-pregnant patients with type 2 diabetes. However, there is no enough clear and strong evidence about the beneficial or adverse effect of SGLT-2 inhibitors usage during pregnancy for management of gestational diabetes (GDM) in human. This short letter discusses challenges in application of SGLT-2 inhibitors in management of GDM. © 2023, Tehran University of Medical Sciences. All rights reserved.