Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Atherogenic Index of Plasma (Aip): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross-Sectional Study Publisher Pubmed



Karimpourreyhan S1 ; Yadegar A1 ; Samimi S1 ; Nakhaei P1 ; Esteghamati A1 ; Nakhjavani M1 ; Karimpourreihan S2 ; Rabizadeh S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Mechanical Engineering School, University of Tehran, Tehran, Iran

Source: Endocrinology, Diabetes and Metabolism Published:2024


Abstract

Background: This study aimed to evaluate the relationships of conventional and calculated lipid indices with obesity or overweight in patients with type 2 diabetes (T2D). Methods: In this cross-sectional study, all participants were categorised into three groups: normal weight (18 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30). Conventional lipid indices, including triglyceride (TG), total cholesterol, LDL-C and HDL-C, were measured. Lipid indices, including the atherogenic index of plasma (AIP), non-HDL-C, TC/HDL-C, LDL-C/HDL-C, non-HLD-C/HDL-C (atherogenic index, AI) and lipoprotein combine index (LCI), were calculated. The associations of these lipid indices with obesity and overweight status were evaluated using univariate and multivariate multinomial logistic regression analyses. Results: In this study, 2661 patients with T2D, including 651 patients with normal weight, 1144 with overweight, and 866 with obesity, were recruited. According to a multinomial logistic regression analysis after adjustment for multiple confounders, the odds ratio (OR) was greater for the AIP than for other conventional and calculated lipid indices in overweight and obese patients with T2D. The AIP had a significant relationship with overweight, with an OR of 4.79 (95% CI: 1.65–13.85), and it had a significant relationship with obesity, with an OR of 13.64 (95% CI: 3.96–47.04). According to the ROC curve, with a cut-off value of 0.68, AIP could predict obesity with 82% sensitivity and 55% specificity (AUC = 0.770, 95% CI: 0.729–0.812, p < 0.001). Conclusion: Compared with other conventional and calculated lipid markers, the AIP is most strongly associated with obesity and overweight in patients with T2D. © 2024 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Atherogenic Index of Plasma Is an Independent Predictor of Metabolic-Associated Fatty Liver Disease in Patients With Type 2 Diabetes, European Journal of Medical Research (2022)
2. Atherogenic Index of Plasma and Coronary Artery Disease: A Systematic Review and Meta-Analysis of Observational Studies, Cardiovascular Diabetology (2025)
3. Methodological Insights Into Chatgpt’S Screening Performance in Systematic Reviews, BMC Medical Research Methodology (2024)
4. Surrogate Markers of Insulin Resistance and Coronary Artery Disease in Type 2 Diabetes: U-Shaped Tyg Association and Insights From Machine Learning Integration, Lipids in Health and Disease (2025)
5. Predicting the Covid-19 Mortality Among Iranian Patients Using Tree-Based Models: A Cross-Sectional Study, Health Science Reports (2023)
6. Effect of Bariatric Surgery on Atherogenicity and Insulin Resistance in Patients With Obesity Class Ii: A Prospective Study, BMJ Open (2023)
7. What Features Predict Poorer Outcomes in Micropapillary Thyroid Carcinoma? a Retrospective Cohort Study, Endocrine Practice (2025)
8. Impact of Gender on Chronic Complications in Participants With Type 2 Diabetes: Evidence From a Cross-Sectional Study, Endocrinology# Diabetes and Metabolism (2024)
Experts (# of related papers)
View all Related Experts
Soghra Rabizadeh (5)
Alireza Esteghamati (5)
Other Related Docs
9. Association of Plant-Based Diets With Adropin, Atherogenic Index of Plasma, and Metabolic Syndrome and Its Components: A Cross-Sectional Study on Adults, Frontiers in Nutrition (2023)
10. Association Between Prediagnostic Risk Factors and Survival After Colorectal Cancer Diagnosis in Golesten Cohort Study, Scientific Reports (2025)
11. Burden of Hand Osteoarthritis in the Middle East and North Africa (Mena): An Epidemiological Analysis From 1990 to 2019, Journal of Hand Surgery (2023)
12. Association Between Dash and Novel Atherogenic Risk Factors, Anthropometric Indices and Foot Ulcer Indicators in Type 2 Diabetic Patients With Foot Ulcer: A Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2024)
13. Increasing Burden of Upper-Extremity Fractures in the Middle East and North Africa (Mena): A 30-Year Analysis of the Epidemiology and Causes of Injuries, Journal of Bone and Joint Surgery (2024)
14. Increasing Burden of Lower-Extremity Fractures in the Middle East and North Africa (Mena) a 30-Year Epidemiological Analysis, Journal of Bone and Joint Surgery (2024)
15. Impaired Fasting Glucose and Major Adverse Cardiovascular Events by Hypertension and Dyslipidemia Status: The Golestan Cohort Study, BMC Cardiovascular Disorders (2020)
16. Prescription Patterns and the Cost of Antihyperglycemic Drugs in Patients With Diabetes Mellitus in Iran From 2014 to 2019, Diabetes Research and Clinical Practice (2025)
17. Apoa1/Hdl-C Ratio As a Predictor for Coronary Artery Disease in Patients With Type 2 Diabetes: A Matched Case-Control Study, BMC Cardiovascular Disorders (2024)
18. Machine Learning Prediction of One-Year Mortality After Percutaneous Coronary Intervention in Acute Coronary Syndrome Patients, International Journal of Cardiology (2024)
19. The Association of the Steatosis Severity, Nafld Fibrosis Score and Fib-4 Index With Atherogenic Dyslipidaemia in Adult Patients With Nafld: A Cross-Sectional Study, International Journal of Clinical Practice (2021)