Correlations Between Histopathologic Changes and Clinical Features in Pterygia

Correlations Between Histopathologic Changes and Clinical Features in Pterygia Publisher

Safi H¹ ; Kheirkhah A² ; Mahbod M³ ; Molaei S³ ; Hashemi H^{3, 4} ; Jabbarvand M⁴

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1. Department of Ophthalmology, Shahid Sadoughi Hospital, Yazd University of Medical Sciences, Shahid Ghandi Blvd, Ebne Sina Ave, Yazd, 89158, Iran
2. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, United States
3. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
4. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Ophthalmic and Vision Research Published:2016

Abstract

Purpose: To investigate the correlations between clinical findings and histopathologic changes in eyes with pterygium. Methods: This prospective study included 70 eyes with primary pterygia undergoing surgical excision. Prior to surgery, clinical features of the pterygia including extension over the cornea, redness, fleshiness (based on obscuration of the underlying episcleral vessels), and obliteration of the plica semilunaris were determined. Postoperatively, pterygium specimens were examined by hematoxylin-eosin and trichrome staining to evaluate histopathologic characteristics including vascular density, leukocytic infiltration, stromal elastosis, stromal fibrosis and subepithelial fibrosis. Correlations between clinical findings and histopathologic changes were then investigated. Results: There was a marginally significant correlation between the redness and the fleshiness of pterygium (P = 0.06). Both redness and fleshiness of the pterygium had significant positive correlation with dimensions of the lesion over the cornea. Moreover, larger pterygia were associated with obliteration of the plica semilunaris. Pterygium redness showed a significant correlation with vascular density (P = 0.04), and pterygium fleshiness had a significant correlation with stromal fibrosis (P = 0.04). Pterygium dimensions over the cornea demonstrated a positive correlation with vascular density and a negative correlation with stromal elastosis. Conclusion: Redness and fleshiness of pterygium were only marginally correlated with each other, and each one showed a correlation with different histopathologic features. Larger pterygia were associated with more significant changes at the clinical and histopathologic levels. © 2016 Journal of Ophthalmic and Vision Research.

Style	Citing Format
MLA	Safi H, et al.. "Correlations Between Histopathologic Changes and Clinical Features in Pterygia." Journal of Ophthalmic and Vision Research, vol. 11, no. 2, 2016, pp. 153-158.
APA	Safi H, Kheirkhah A, Mahbod M, Molaei S, Hashemi H, Jabbarvand M (2016). Correlations Between Histopathologic Changes and Clinical Features in Pterygia. Journal of Ophthalmic and Vision Research, 11(2), 153-158.
Chicago	Safi H, Kheirkhah A, Mahbod M, Molaei S, Hashemi H, Jabbarvand M. "Correlations Between Histopathologic Changes and Clinical Features in Pterygia." Journal of Ophthalmic and Vision Research 11, no. 2 (2016): 153-158.
Harvard	Safi H et al. (2016) 'Correlations Between Histopathologic Changes and Clinical Features in Pterygia', Journal of Ophthalmic and Vision Research, 11(2), pp. 153-158.
Vancouver	Safi H, Kheirkhah A, Mahbod M, Molaei S, Hashemi H, Jabbarvand M. Correlations Between Histopathologic Changes and Clinical Features in Pterygia. Journal of Ophthalmic and Vision Research. 2016;11(2):153-158.
BibTex	@article{ author = {Safi H and Kheirkhah A and Mahbod M and Molaei S and Hashemi H and Jabbarvand M}, title = {Correlations Between Histopathologic Changes and Clinical Features in Pterygia}, journal = {Journal of Ophthalmic and Vision Research}, volume = {11}, number = {2}, pages = {153-158}, year = {2016} }
RIS	TY - JOUR AU - Safi H AU - Kheirkhah A AU - Mahbod M AU - Molaei S AU - Hashemi H AU - Jabbarvand M TI - Correlations Between Histopathologic Changes and Clinical Features in Pterygia JO - Journal of Ophthalmic and Vision Research VL - 11 IS - 2 SP - 153 EP - 158 PY - 2016 ER -

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