Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report

Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report Publisher Pubmed

Jamshidiantehrani M¹ ; Mahmoudzadeh R¹ ; Asadi Khameneh E¹ ; Asadi Amoli F² ; Faghih Jouibari M³ ; Kasaee A¹ ; Ghadimi H¹

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1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pathology, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Neurosurgery, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Orbit (London) Published:2020

Abstract

Solitary or isolated neurofibroma is uncommonly observed in the orbit. Neurofibromas typically involve peripheral nerves and occasionally the cranial nerves. A 29-year-old man presented with recent onset left eye proptosis and exotropia. Physical examination was positive for hyperpigmented lesions of the ipsilateral ocular surface and hard palate. Imaging revealed an infiltrative orbital mass with extension through superior orbital fissure into the brain. There was also bone defect of greater sphenoid wing. Medial orbitotomy was performed to obtain biopsies of the orbital mass and the pigmented ocular surface lesions. Histopathologic diagnosis of neurofibroma was confirmed for the former and melanocytoma for the latter. His symptoms and examinations remained stable during the follow up. This case is unique due to several features, including extensive intracerebral spread of orbital neurofibroma in a patient without definite diagnosis of neurofibromatosis type 1 and association with ipsilateral ocular surface melanocytoma and palatal pigmented lesions. Abbreviations: CT: computed tomography; GFAP: glial fibrillary acid protein; MRI: magnetic resonance imaging; NF-1: neurofibromatosis type 1. © 2019 Taylor & Francis Group, LLC.

Style	Citing Format
MLA	Jamshidiantehrani M, et al.. "Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report." Orbit (London), vol. 39, no. 5, 2020, pp. 368-373.
APA	Jamshidiantehrani M, Mahmoudzadeh R, Asadi Khameneh E, Asadi Amoli F, Faghih Jouibari M, Kasaee A, Ghadimi H (2020). Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report. Orbit (London), 39(5), 368-373.
Chicago	Jamshidiantehrani M, Mahmoudzadeh R, Asadi Khameneh E, Asadi Amoli F, Faghih Jouibari M, Kasaee A, Ghadimi H. "Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report." Orbit (London) 39, no. 5 (2020): 368-373.
Harvard	Jamshidiantehrani M et al. (2020) 'Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report', Orbit (London), 39(5), pp. 368-373.
Vancouver	Jamshidiantehrani M, Mahmoudzadeh R, Asadi Khameneh E, Asadi Amoli F, Faghih Jouibari M, Kasaee A, et al.. Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report. Orbit (London). 2020;39(5):368-373.
BibTex	@article{ author = {Jamshidiantehrani M and Mahmoudzadeh R and Asadi Khameneh E and Asadi Amoli F and Faghih Jouibari M and Kasaee A and Ghadimi H}, title = {Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report}, journal = {Orbit (London)}, volume = {39}, number = {5}, pages = {368-373}, year = {2020} }
RIS	TY - JOUR AU - Jamshidiantehrani M AU - Mahmoudzadeh R AU - Asadi Khameneh E AU - Asadi Amoli F AU - Faghih Jouibari M AU - Kasaee A AU - Ghadimi H TI - Solitary Neurofibroma of the Orbit With Intracerebral Extension Associated With Ocular Surface Melanocytoma: A Case Report JO - Orbit (London) VL - 39 IS - 5 SP - 368 EP - 373 PY - 2020 ER -

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Abstract