Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Ginger (Zingiber Officinale) on Blood Glucose and Lipid Concentrations in Diabetic and Hyperlipidemic Subjects: A Meta-Analysis of Randomized Controlled Trials Publisher



Jafarnejad S1 ; Keshavarz SA1 ; Mahbubi S2 ; Saremi S3 ; Arab A4 ; Abbasi S5 ; Djafarian K1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Community Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Faculty of Public Health, Kermanshah University of Medical Science, Kermanshah, Iran

Source: Journal of Functional Foods Published:2017


Abstract

Objective The aim of our study was to assess the effect of ginger (Zingiber officinale) on blood glucose and lipid concentration in subjects with diabetes or hyperlipidemia. Methods The literature search was conducted in PubMed and Scopus up to 30 October 2016. A total of nine randomized controlled trials were included in the meta-analysis. Weighted mean difference (WMD) and its 95% confidence interval were calculated for net changes in blood glucose (fasting blood-glucose [FBG]) and lipid concentrations (total cholesterol [TC], triglyceride [TG], low-density lipoprotein cholesterol [LDL-C], high density lipoprotein cholesterol [HDL-C]). Subgroup analyses were performed by clinical condition (hyperlipidemia and T2DM) and quality assessment (high and low quality). Results Compared to the controls, ginger intake significantly reduced the concentrations of TG (WMD, −8.84; 95% CI: −11.95 to −5.73), TC (WMD, −4.42; 95% CI: −8.70 to −0.13), HDL-C (WMD, 2.87; 95% CI: 0.88–4.86) and FBG (WMD = −14.93; 95% CI: −19.83 to −10.04). Subgroup analyses by clinical condition of hyperlipidemia and high quality studies showed consistent results with the overall analysis, whereas, the subgroup analysis by clinical condition of diabetes showed a significant difference in the mean change of TG and FBG levels. Moreover, the high risk studies showed a significant change in the mean of FBG. Examining the funnel plot, suggests no publication bias. Conclusions Ginger supplementation (tablet, capsules, powder or rhizomes) significantly reduced FBG, TG and TG and significantly increased HDL-C. But the changes were related to the clinical condition. More clinical trials evaluating the effects of ginger are warranted. © 2016 Elsevier Ltd
Related Docs
View other Related Docs
1. Effects of Ginger Supplementation on Anthropometric, Glycemic and Metabolic Parameters in Subjects With Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study, Journal of Diabetes and Metabolic Disorders (2019)
2. Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial, Peritoneal Dialysis International (2016)
3. Effects of Ginger on Serum Glucose, Advanced Glycation End Products, and Inflammation in Peritoneal Dialysis Patients, Nutrition (2015)
4. Ginger Intervention on Body Weight and Body Composition in Adults: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of 27 Randomized Controlled Trials, Nutrition Reviews (2024)
5. The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients With Type 2 Diabetes, International Journal of Endocrinology and Metabolism (2017)
6. Ginger From Ancient Times to the New Outlook, Jundishapur Journal of Natural Pharmaceutical Products (2015)
7. Bioactive Foods and Medicinal Plants for Cardiovascular Complications of Type Ii Diabetes: Current Clinical Evidence and Future Perspectives, Evidence-based Complementary and Alternative Medicine (2021)
8. Ginger: A Complementary Approach for Management of Cardiovascular Diseases, BioFactors (2021)
Experts (# of related papers)
View all Related Experts
Kurosh Djafarian (3)
Leila Azadbakht (2)
Other Related Docs
9. Effects of Ginger Supplementation on Biomarkers of Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2021)
10. The Effect of Ginger (Zingiber Officinale) on Glycemic Markers in Patients With Type 2 Diabetes, Journal of Complementary and Integrative Medicine (2015)
11. A Systematic Review of the Efficacy of Alternative Medicine in the Treatment of Nausea and Vomiting of Pregnancy, Journal of Obstetrics and Gynaecology (2020)
12. The Effect of Ginger Supplementation on Il2, Tnfα, and Il1β Cytokines Gene Expression Levels in Patients With Active Rheumatoid Arthritis: A Randomized Controlled Trial, Medical Journal of the Islamic Republic of Iran (2019)
13. The Effects of Omega-3 Supplementation on Resting Metabolic Rate: A Systematic Review and Meta-Analysis of Clinical Trials, Evidence-based Complementary and Alternative Medicine (2021)
14. A Randomized, Double-Blind Placebo-Controlled Phase I Clinical Study on Safety and Efficacy of the G-Rup® Syrup (A Mixture of Ginger Extract and Honey) in Symptomatic Treatment of Knee Osteoarthritis, Journal of Clinical Pharmacy and Therapeutics (2022)
15. Beneficiary Effect of A-Lipoic Acid Supplementation on C-Reactive Protein Level Among Adults: A Systematic Review and Meta-Analysis of Randomized Control Trials, Nutrition and Food Science (2018)
16. Protective Effect of Ginger (Zingiber Officinale Roscoe) Extract Against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1Β in Cultured Chondrocytes, Cells Tissues Organs (2017)
17. Effects of Herbal Medicines on the Prevention and Treatment of Contact Dermatitis: A Systematic Review, Iranian Journal of Public Health (2022)
18. Effect of Nigella Sativa Supplementation on Obesity Indices: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2018)
19. Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases, International Journal of Nanomedicine (2021)
20. The Effects of Curcumin Supplementation on Body Weight, Body Mass Index and Waist Circumference: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Critical Reviews in Food Science and Nutrition (2020)
21. The Effect of Ginger-Chamomile Sachet With Honey on Primary Dysmenorrhea and Associated Symptoms: A Randomized, Double-Blind, Controlled Trial, Current Women's Health Reviews (2020)
22. The Effect of Crocin Supplementation on Lipid Concentrations and Fasting Blood Glucose: A Systematic Review and Meta-Analysis and Meta-Regression of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
23. Effect of Vitamin E Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis, Journal of Human Hypertension (2019)
24. Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study, Hepatitis Monthly (2016)
25. The Effects of Sesame Consumption on Glycemic Control in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trial, Evidence-based Complementary and Alternative Medicine (2021)
26. Effect of Alpha-Lipoic Acid Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Controlled Clinical Trials, Nutrition (2019)
27. Nigella Sativa Improves Glucose Homeostasis and Serum Lipids in Type 2 Diabetes: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2017)
28. The Effects of Supplementation With Probiotic on Biomarkers of Oxidative Stress in Adult Subjects: A Systematic Review and Meta-Analysis of Randomized Trials, Probiotics and Antimicrobial Proteins (2020)
29. The Effect of Curcumin Supplementation on Circulating Adiponectin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
30. Does Ginger Supplementation Lower Blood Pressure? a Systematic Review and Meta-Analysis of Clinical Trials, Phytotherapy Research (2019)
31. The Effect of Zinc Supplementation on Serum Leptin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Hormone and Metabolic Research (2019)