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Synthesis, Characterization, and Induced Osteogenic Differentiation Effect of Collagen Membranes Functionalized by Polydopamine/Graphene Oxide for Bone Tissue Engineering Publisher Pubmed



Davaie S1 ; Hooshmand T2 ; Najafi F3 ; Haghbin Nazarpak M4 ; Pirmoradian M1
Authors
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Authors Affiliations
  1. 1. Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, 1439955991, Iran
  2. 2. Dental Research Center, Dentistry Research Institute/School of Dentistry, Tehran University of Medical Sciences, Tehran, 1439955991, Iran
  3. 3. Department of Resin and Additives, Institute for Color Science and Technology, Tehran, 1668814811, Iran
  4. 4. New Technology Research Center, Amirkabir University of Technology, Tehran, 1591634653, Iran

Source: ACS Applied Bio Materials Published:2023


Abstract

Collagen is one of the most common natural absorbable polymers, which is widely used as a barrier membrane in biomedical fields due to its many desirable biological properties. However, absorbable membranes such as collagen have their own disadvantages such as unpredictable degradation rates, poor rigidity leading to tissue collapse, and limited osteogenic properties and cell adhesion. In this study, a modified collagen membrane with a polydopamine-graphene oxide (PDA/GO) complex was synthesized to improve the characteristics of collagen for bone tissue engineering. The successful synthesis of PDA/GO on collagen membranes was verified using X-ray photoelectron spectroscopy (XPS) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The wettability of PDA/GO-modified collagen membranes was considerably improved based on the characterization by water contact angle compared to the uncoated membranes and surface coatings solely by either PDA or GO. The modified PDA/GO coating also enhanced the mechanical properties such as tensile strength and biodegradation rate of collagen membranes. In addition, the PDA/GO coating effectively enhanced the biocompatibility of collagen membranes as verified by the enhanced proliferation and adhesion of human bone marrow stem cells (hBMSCs). Additionally, the effects of PDA/GO coating on the osteogenic differentiation of hBMSCs on collagen membranes were investigated through alkaline phosphatase (ALP) activity and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The PDA/GO coating on collagen membranes resulted in a significant increase in osteogenic properties compared with the uncoated collagen membranes. According to the results of the current study, the combination of PDA and GO-modified collagen membranes could be used for bone tissue engineering and biomedical applications. © 2023 American Chemical Society.
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