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Hla-Drb1 Polymorphism and Susceptibility to Multiple Sclerosis in the Middle East North Africa Region: A Systematic Review and Meta-Analysis Publisher Pubmed



Mohajer B1, 2, 4 ; Abbasi N1, 4 ; Pishgar F2 ; Abdolalizadeh A1, 4 ; Ebrahimi H2 ; Razaviyoun T3 ; Mohebbi F1, 2 ; Eskandarieh S1 ; Sahraian MA1
Authors
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Authors Affiliations
  1. 1. MS Research Centre, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Neuroimmunology Published:2018


Abstract

This meta-analysis explores association of HLA-DRB1 alleles with MS risk in the Middle-east North Africa (MENA) countries. Divided into two groups of alleles (10 studies, 899 cases/1457 controls) and phenotypes (8 studies, 1,040 cases/1,256 controls), Odds ratios (ORs) of DRB1 distribution in MS subjects were assessed using Cochrane RevMan software. DRB1*15 demonstrated significant association with MS in both groups (OR=1.6 and OR=2.51, respectively). In phenotypes, DRB1*03 and DRB1*04 had predisposing role (OR=1.8 and OR=1.9), while DRB1*07 and DRB1*11 were protective (OR=0.56 and OR=0.67). Similar but non-significant trends were seen among alleles, which in sum coincides with a Caucasian-like pattern. © 2018 Elsevier B.V.
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