Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population

Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population Publisher Pubmed

Ehsan S¹ ; Amirzargar A^{2, 3} ; Yekaninejad MS⁴ ; Mahmoudi M⁵ ; Mehravar S⁴ ; Moradi B^{2, 3} ; Nafissi S¹

Show Affiliations

1. Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, North Karegar Street, Tehran, 14114, Iran
2. Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5. Rheumatology Research Center (RRC), Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Neurological Sciences Published:2015

Abstract

Heterogenic pattern of HLA associations with myasthenia gravis (MG) among different ethnicities and also among different MG subgroups has been the subject of debate in large series of many studies. One hundred and sixty Iranian MG patients were investigated for HLA class II (DRB1, DQA1, DQB1) associations compared to two hundred healthy controls from the same ethnic population. DRB1∗11 DQA1∗0501 DQB1∗0301 haplotype was found to be protective for total (ocular plus generalized) MG (Pc = 0.005, OR = 0.49) and generalized MG (Pc = 0.008, OR = 0.49). DRB1∗04 DQA1∗0301 DQB1∗0302 haplotype (Pc = 0.03, OR = 2.25) was predisposing for anti-acetylcholine receptor (AChR) antibody-positive MG, while DRB1∗16 DQA1∗0102 DQB1∗05 (Pc = 0.013, OR = 4.28) was predisposing for anti-muscle specific tyrosine kinase (MuSK) antibody-positive MG. There was also a trend of positive association for DRB1∗14 DQA1∗0104 DQB1∗05 haplotype with MuSK-positive MG (Pc = 0.054, OR = 3.97). Among other MG subgroups and with less significance, DRB1∗0101 DQA1∗0101 DQB1∗05 haplotype (P = 0.016, OR = 3.68) had positive association with pure ocular MG, and DRB1∗03 DQA1∗0501 DQB1∗0201 haplotype (P = 0.024) had negative association with thymomatous MG. This study highlights the importance of appropriate MG subgrouping according to clinical and paraclinical characteristics in HLA studies among MG patients. © 2015 Elsevier B.V.

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Style	Citing Format
MLA	Ehsan S, et al.. "Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population." Journal of the Neurological Sciences, vol. 359, no. 1-2, 2015, pp. 335-342.
APA	Ehsan S, Amirzargar A, Yekaninejad MS, Mahmoudi M, Mehravar S, Moradi B, Nafissi S (2015). Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population. Journal of the Neurological Sciences, 359(1-2), 335-342.
Chicago	Ehsan S, Amirzargar A, Yekaninejad MS, Mahmoudi M, Mehravar S, Moradi B, Nafissi S. "Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population." Journal of the Neurological Sciences 359, no. 1-2 (2015): 335-342.
Harvard	Ehsan S et al. (2015) 'Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population', Journal of the Neurological Sciences, 359(1-2), pp. 335-342.
Vancouver	Ehsan S, Amirzargar A, Yekaninejad MS, Mahmoudi M, Mehravar S, Moradi B, et al.. Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population. Journal of the Neurological Sciences. 2015;359(1-2):335-342.
BibTex	@article{ author = {Ehsan S and Amirzargar A and Yekaninejad MS and Mahmoudi M and Mehravar S and Moradi B and Nafissi S}, title = {Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population}, journal = {Journal of the Neurological Sciences}, volume = {359}, number = {1-2}, pages = {335-342}, year = {2015} }
RIS	TY - JOUR AU - Ehsan S AU - Amirzargar A AU - Yekaninejad MS AU - Mahmoudi M AU - Mehravar S AU - Moradi B AU - Nafissi S TI - Association of Hla Class Ii (Drb1, Dqa1, Dqb1) Alleles and Haplotypes With Myasthenia Gravis and Its Subgroups in the Iranian Population JO - Journal of the Neurological Sciences VL - 359 IS - 1-2 SP - 335 EP - 342 PY - 2015 ER -

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