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Lineages and Sublineages of Human Papillomavirus Type 16 in Cervical Samples of Iranian Women Publisher



Salehivaziri M1, 2 ; Sadeghi F2, 3 ; Haeri H4 ; Bokharaeisalim F5 ; Monavari SH5 ; Hashemi FS6 ; Jalilvand S2 ; Keyvani H5
Authors
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Authors Affiliations
  1. 1. Department of Arboviruses and Viral Hemorrhagic Fever, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology & Microbiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  4. 4. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Gynecology Oncology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2023


Abstract

Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16) and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16 variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based on our data, the predominant HPV16 lineage was D and there was a significant association between lineage D variants and cervical cancer. © 2023 Future Medicine Ltd.
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