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Remdesivir-Associated Significant Bradycardia: A Report of Three Cases Publisher



Shirvani M1 ; Sayad B1 ; Shojaei L2 ; Amini A3 ; Shahbazi F2
Authors
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Authors Affiliations
  1. 1. Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Clinical Pharmacy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Tehran University Heart Center Published:2021


Abstract

Recently, remdesivir was approved by the United States Food and Drug Administration for patients with Coronavirus disease 2019 (COVID-19). We herein describe 3 patients with COVID-19 who showed significant bradycardia and QTc prolongation after remdesivir administration. Bradycardia did not respond to atropine treatment in 2 of the patients, one of whom received theophylline and the other required a temporary pacemaker. Fortunately, the patients’ heart rate and rhythm returned to normal after the discontinuation of remdesivir, albeit it lengthened their hospital stays. Careful monitoring during remdesivir infusion may decrease the risk of adverse cardiovascular side effects. © 2021 Tehran University of Medical Sciences.
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