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Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (Covid-19) Publisher Pubmed



Dixon DL1, 2 ; Van Tassell BW1, 2 ; Vecchie A2 ; Bonaventura A2, 3 ; Talasaz AH4 ; Kakavand H4 ; Dascenzo F5 ; Perciaccante A6 ; Castagno D5 ; Ammirati E7 ; Biondizoccai G8, 9 ; Stevens MP10 ; Abbate A2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, VA, United States
  2. 2. Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States
  3. 3. Department of Internal Medicine, First Clinic of Internal Medicine, University of Genoa, Genoa, Italy
  4. 4. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Division of Cardiology, Department of Medical Science, University of Turin, Turin, Italy
  6. 6. Department of Medicine, University Health Agency Giuliano Isontina, 'San Giovanni di Dio' Hospital, Gorizia, Italy
  7. 7. Department of Cardiology, Niguarda Hospital, Milan, Italy
  8. 8. Department of Medico-Surgical Sciences and Biotechnologies Sapienza, University of Rome, Rome, Italy
  9. 9. Mediterranea Cardiocentro, Napoli, Italy
  10. 10. Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, United States

Source: Journal of Cardiovascular Pharmacology Published:2020


Abstract

A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly across the globe since December 2019. Coronavirus disease 2019 (COVID-19) has a significantly higher mortality rate than seasonal influenza and has disproportionately affected older adults, especially those with cardiovascular disease and related risk factors. Adverse cardiovascular sequelae, such as myocarditis, acute myocardial infarction, and heart failure, have been reported in patients with COVID-19. No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. Considering these therapies are not familiar to cardiovascular clinicians managing these patients, this review describes the pharmacology of these therapies in the context of their use in patients with cardiovascular-related conditions. © 2020 Lippincott Williams and Wilkins. All rights reserved.
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