Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series

Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series Publisher Pubmed

Mohammadpour Lashkari F¹ ; Sadighi Gilani MA^{1, 2} ; Ghaheri A³ ; Zamanian MR⁴ ; Borjian Boroujeni P⁴ ; Mohseni Meybodi A⁴ ; Sabbaghian M¹

Show Affiliations

1. Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
2. Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
4. Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

Source: Andrologia Published:2018

Abstract

Disorders of sex development (DSD) are congenital abnormalities as an atypical development process in either gonadal or chromosomal structure. It is the cause of the abnormality in phenotype and characteristics. Chromosomal analysis plays an important role in the DSD determination. 45,X/46,XY mosaicism is a rare karyotype, and its prevalence is about 1.5 in 10,000 newborns. It affects the growth, hormonal balance, gonad development and histology. All data such as height, male general appearance, testis size and volume, external genitalia, spermogram and hormonal levels, testis pathology, Y chromosome microdeletion and karyotype, and assisted reproductive technology (ART) outcome were recorded based on patients profile and history. We investigated 64 infertile males with 45,X/46,XY mosaicism. Fifteen cases who had structural abnormalities in Y chromosome were excluded. From 49 available spermogram, 21 cases reported as azoospermic men, while 28 of them classified as nonazoospermic patients in which four of them displayed normal spermogram. According to hormonal evaluation, there were no significant differences between azoospermic and nonazoospermic groups. In azoospermia, only three couples underwent an ART cycle in which all of them failed. From 14 nonazoospermic cases who entered into the ART cycle, three cases experienced a successful pregnancy that one of the prosperous outcomes was twins. In 45,X/46,XY cases, both 45,X and 46,XY cell lines are seen. Various distributions of both cell lines can reflect a wide range of phenotypes that may be the most comprehensive evaluation in infertile males with 45,X/46,XY karyotype. It assumes that karyotyping as a main diagnostic test can enable us to find these rare cases. © 2018 Blackwell Verlag GmbH

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Style	Citing Format
MLA	Mohammadpour Lashkari F, et al.. "Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series." Andrologia, vol. 50, no. 5, 2018, pp. -.
APA	Mohammadpour Lashkari F, Sadighi Gilani MA, Ghaheri A, Zamanian MR, Borjian Boroujeni P, Mohseni Meybodi A, Sabbaghian M (2018). Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series. Andrologia, 50(5), -.
Chicago	Mohammadpour Lashkari F, Sadighi Gilani MA, Ghaheri A, Zamanian MR, Borjian Boroujeni P, Mohseni Meybodi A, Sabbaghian M. "Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series." Andrologia 50, no. 5 (2018): -.
Harvard	Mohammadpour Lashkari F et al. (2018) 'Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series', Andrologia, 50(5), pp. -.
Vancouver	Mohammadpour Lashkari F, Sadighi Gilani MA, Ghaheri A, Zamanian MR, Borjian Boroujeni P, Mohseni Meybodi A, et al.. Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series. Andrologia. 2018;50(5):-.
BibTex	@article{ author = {Mohammadpour Lashkari F and Sadighi Gilani MA and Ghaheri A and Zamanian MR and Borjian Boroujeni P and Mohseni Meybodi A and Sabbaghian M}, title = {Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series}, journal = {Andrologia}, volume = {50}, number = {5}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Mohammadpour Lashkari F AU - Sadighi Gilani MA AU - Ghaheri A AU - Zamanian MR AU - Borjian Boroujeni P AU - Mohseni Meybodi A AU - Sabbaghian M TI - Clinical Aspects of 49 Infertile Males With 45,X/46,Xy Mosaicism Karyotype: A Case Series JO - Andrologia VL - 50 IS - 5 SP - EP - PY - 2018 ER -

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