Prevalence of Chromosomal Abnormalities in Iranian Patients With Infertility Publisher Pubmed



Abbaspour S¹ ; Isazadeh A² ; Heidari M³ ; Heidari M³ ; Hajazimian S² ; Soleymannejad M³ ; Taskhiri MH³ ; Bolhassani M³ ; Ebrahimi AH³ ; Keshavarz P¹ ; Shiri Z³ ; Heidari M³
Source: Archives of Iranian Medicine Published:2023

Abstract

Background: The numerical and structural abnormalities of chromosomes are the most common cause of infertility. Here, we evaluated the prevalence and types of chromosomal abnormalities in Iranian infertile patients. Methods: We enrolled 1750 couples of reproductive age with infertility, who referred to infertility clinics in Tehran during 2014-2019, in order to perform chromosomal analysis. Peripheral blood samples were obtained from all couples and chromosomal abnormalities were evaluated by G-banded metaphase karyotyping. In some cases, the detected abnormalities were confirmed using fluorescence in-situ hybridization (FISH). Results: We detected various chromosomal abnormalities in 114/3500 (3.257%) patients with infertility. The prevalence of chromosomal abnormalities was 44/114 (38.596%) among infertile females and 70/114 (61.403%) among infertile males. Structural chromosomal abnormalities were found in 27/1750 infertile females and 35/1750 infertile males. Numerical chromosomal abnormalities were found in 17/1750 of females and 35/1750 of males. The 45, XY, rob (13;14) (p10q10) translocation and Klinefelter syndrome (47, XXY) were the most common structural and numerical chromosomal abnormalities in the Iranian infertile patients, respectively. Conclusion: In general, we found a high prevalence of chromosomal abnormalities in Iranian patients with reproductive problems. Our study highlights the importance of cytogenetic studies in infertile patients before starting infertility treatments approaches. © 2023 Academy of Medical Sciences of I.R. Iran. All rights reserved.