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Htlv-1 Infection and Micrornas: Unraveling the Complex Crosstalk Publisher



Edalat F1 ; Letafati A2, 3 ; Kaghazchi T3 ; Sadeghi M3 ; Taheri A4 ; Shikki A5 ; Garkani SH3 ; Afrozi M3 ; Norouzi M2 ; Mozhgani SH6
Authors
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Authors Affiliations
  1. 1. Autophagy Research Center, Shiraz University of Medical Science, Shiraz, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, Shahed University, Tehran, Iran
  5. 5. Department of Microbiology, Shahed University, Tehran, Iran
  6. 6. Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Alborz, Karaj, Iran

Source: Infectious Agents and Cancer Published:2025


Abstract

Human T-cell leukemia virus type 1 (HTLV-1) retrovirus that infects millions of individuals worldwide, have caused severe diseases like adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite extensive research efforts, the underlying mechanisms leading to HTLV-1 pathogenesis remain incompletely understood. New research has revealed that microRNAs (miRNAs) play a crucial role in the complex interplay between HTLV-1 infection and host cellular responses. This review highlights the multifaceted interactions between HTLV-1 and miRNAs, encompassing both viral manipulation of cellular miRNA networks and host miRNA-mediated responses. Gaining a comprehensive understanding of the complex interconnection between HTLV-1 infection and miRNAs provides a significant opportunity for discovering innovative therapeutic approaches and creating advanced diagnostic tools aimed in HTLV-1 treatment. © The Author(s) 2025.
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