The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis

The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis Publisher

Khosravi A¹ ; Alizadeh S² ; Jalili A³ ; Shirzad R⁴ ; Saki N⁵

Show Affiliations

1. Transfusion Research Center, High Institute for Research and Education in Transfusion Medi-cine, Tehran, Iran
2. Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Stem Cells and Developmental Biology, Cell Science Re-search Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
4. WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
5. Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jun-dishapur University of Medical Sciences, Ahvaz, Iran

Source: Oncology Reviews Published:2018

Abstract

MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neoplasia, prognosis, and treatment approaches. We have shown that a large number of MiR-9 targets (such as FOXOs, SIRT1, CCND1, ID2, CCNG1, Ets, and NFkB) play essential roles in leukemogenesis and that it is overexpressed in different leukemias. Our findings indicated MiR-9 downregulation in a majority of leukemias. However, its overexpression was reported in patients with dysregulated MiR-9 controlling factors (such as MLLr). Additionally, prognostic value of MiR-9 has been reported in some types of leukemia. This study generally emphasizes on the critical role of MiR-9 in hematologic malignancies as a prognostic factor and a therapeutic target. © CopyrightA. Khosravi et al., 2018.

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Style	Citing Format
MLA	Khosravi A, et al.. "The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis." Oncology Reviews, vol. 12, no. 1, 2018, pp. 22-32.
APA	Khosravi A, Alizadeh S, Jalili A, Shirzad R, Saki N (2018). The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis. Oncology Reviews, 12(1), 22-32.
Chicago	Khosravi A, Alizadeh S, Jalili A, Shirzad R, Saki N. "The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis." Oncology Reviews 12, no. 1 (2018): 22-32.
Harvard	Khosravi A et al. (2018) 'The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis', Oncology Reviews, 12(1), pp. 22-32.
Vancouver	Khosravi A, Alizadeh S, Jalili A, Shirzad R, Saki N. The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis. Oncology Reviews. 2018;12(1):22-32.
BibTex	@article{ author = {Khosravi A and Alizadeh S and Jalili A and Shirzad R and Saki N}, title = {The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis}, journal = {Oncology Reviews}, volume = {12}, number = {1}, pages = {22-32}, year = {2018} }
RIS	TY - JOUR AU - Khosravi A AU - Alizadeh S AU - Jalili A AU - Shirzad R AU - Saki N TI - The Impact of Mir-9 Regulation in Normal and Malignant Hematopoiesis JO - Oncology Reviews VL - 12 IS - 1 SP - 22 EP - 32 PY - 2018 ER -

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