Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock

Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock Publisher

Alrikabi SK^{1, 2} ; Fathi H³ ; Rahmati J³

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1. Fellowship Plastic and Reconstructive Surgery, Tehran University of Medical Science, Iran
2. Health Ministry of Iraq, Thi Qar Health Directorate, Iraq
3. Department of Plastic and Reconstructive Surgery, Tehran University of Medical Science, Iran

Source: Systematic Reviews in Pharmacy Published:2020

Abstract

Background: Despite important advances in understanding the pathophysiology of sepsis, the mortality it generates remains high. Objective: Describe the state of the art of molecular biomarkers proposed so far as potential markers for the diagnosis and prognosis of sepsis, severe sepsis and septic shock. Results: The search yielded 3,370 references covering more than 30 genes with genetic polymorphisms that can be used as potential polymorphism markers. These were evaluated for its use in the different manifestations of sepsis, its diagnosis and progression. Twenty marker genes are described: four associated with bacteremia (TLR-1, TLR-2, Protein C and Selectin-E), nine with sepsis (IL-1B, IL-1A, IL-6, TNF-α, TLR-1, MBL-1, Hsp70, PAI-1 and MIF-1), seven with severe sepsis (IL-1RN, IL-10, TNF-α, CD14, TREM1, Caspasa 12 and DEFB-1), five with shock septic (TNF-B, TLR-4, Hsp70, MBL-1 and CD14) and three with dysfunction multi-organ (TLR-1, PAI-1 and Protein C). Conclusion: Genetic polymorphisms, for the most part, have have been clinically proven as diagnostic markers and prognosis in sepsis with promising results due to discharge specificity and sensitivity in clinical practice. © 2020 EManuscript Technologies. All rights reserved.

Style	Citing Format
MLA	Alrikabi SK, Fathi H, Rahmati J. "Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock." Systematic Reviews in Pharmacy, vol. 11, no. 6, 2020, pp. 101-111.
APA	Alrikabi SK, Fathi H, Rahmati J (2020). Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. Systematic Reviews in Pharmacy, 11(6), 101-111.
Chicago	Alrikabi SK, Fathi H, Rahmati J. "Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock." Systematic Reviews in Pharmacy 11, no. 6 (2020): 101-111.
Harvard	Alrikabi SK, Fathi H, Rahmati J (2020) 'Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock', Systematic Reviews in Pharmacy, 11(6), pp. 101-111.
Vancouver	Alrikabi SK, Fathi H, Rahmati J. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. Systematic Reviews in Pharmacy. 2020;11(6):101-111.
BibTex	@article{ author = {Alrikabi SK and Fathi H and Rahmati J}, title = {Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock}, journal = {Systematic Reviews in Pharmacy}, volume = {11}, number = {6}, pages = {101-111}, year = {2020} }
RIS	TY - JOUR AU - Alrikabi SK AU - Fathi H AU - Rahmati J TI - Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock JO - Systematic Reviews in Pharmacy VL - 11 IS - 6 SP - 101 EP - 111 PY - 2020 ER -

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Abstract